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Tel: 86-371-86259723
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Tel: 17734809689
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Tel: +86-371- 86259723
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CAS NO.97322-87-7
| Troglitazone Basic information |
| Product Name: | Troglitazone |
| Synonyms: | RESULIN(TM);ROMGLIZONE;TROGLITAZONE;2,4-thiazolidinedione,5-((4-((3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2h-1-b;5-(4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl)thiazolidine-2;ci991;enzopyran-2-yl)methoxy)phenyl)methyl)-;gr92132x |
| CAS: | 97322-87-7 |
| MF: | C24H27NO5S |
| MW: | 441.54 |
| EINECS: | |
| Product Categories: | Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor;Aromatics;Heterocycles;Sulfur & Selenium Compounds |
| Mol File: | 97322-87-7.mol |
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| Troglitazone Chemical Properties |
| Melting point | 184-186°C |
| storage temp. | Store at -20°C |
| solubility | DMSO: 20 mg/mL |
| form | solid |
| color | white to yellow |
| CAS DataBase Reference | 97322-87-7(CAS DataBase Reference) |
| Safety Information |
| Safety Statements | 22-24/25 |
| WGK Germany | 2 |
| RTECS | XJ5813130 |
| Troglitazone Usage And Synthesis |
| Chemical Properties | Crystalline Solid |
| Usage | Troglitazone is an an oral hypoglycemic agent which improves insulin sensitivity and decreases hepatic glucose production. Antidiabetic. |
| Usage | antidiabetic;peroxisome proliferator-activated receptors activator |
| Biological Activity | Selective PPAR γ receptor agonist (EC 50 values are 780 and 555 nM at murine and human PPAR γ receptors respectively). Displays no activity at PPAR α or PPAR δ receptors. Antidiabetic agent; exerts potent glucose-lowering effects in insulin-resistant diabetic mice. Displays anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Also inhibits lamellipodia formation and actin polymerization. |
| Troglitazone Preparation Products And Raw materials |
| Raw materials | p-Hydroxybenzaldehyde-->Trifluoromethanesulfonic anhydride-->2-methylpentane |
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