HENAN SUNLAKE ENTERPRISE CORPORATION
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Tel: 86-371-86259723
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CAS NO.88889-14-9
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
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About Company
| Product Name: | Fosinopril sodium |
| Synonyms: | MONOPRIL;TENSOZIDE;(4S)-4-CYCLOHEXYL-1-[[(R)-[(1S)-2-METHYL-1-(1-OXOPROPOXY)PROPOXY](4-PHENYLBUTYL)PHOSPHINYL]ACETYL]-L-PROLINE;(4s)-4-cyclohexyl-1-{[(rs)-2-methyl-1-(propionyloxy)propoxy]-(4-phenylbutyl)phosphinylacetyl}-l-proline sodium salt;FOSINOPRIL-D5 SODIUM SALT;FOSINOPRIL NA;FOSINOPRIL SODIUM;FOSINOPRIL SODIUM SALT |
| CAS: | 88889-14-9 |
| MF: | C30H46NNaO7P |
| MW: | 586.65 |
| EINECS: | |
| Product Categories: | API;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Chiral Reagents;Phosphorylating and Phosphitylating Agents;Isotope Labelled Compounds;Cardiovascular APIs |
| Mol File: | 88889-14-9.mol |
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| Fosinopril sodium Chemical Properties |
| mp | 196-198°C |
| storage temp. | -20°C Freezer |
| CAS DataBase Reference | 88889-14-9(CAS DataBase Reference) |
| Safety Information |
| Fosinopril sodium Usage And Synthesis |
| Hypotensive drug |
Fosinopril sodium is a unique novel angiotensin converting enzyme inhibitor containing phosphono,it is a sodium of fosinopril , belonging to lowering blood pressure drugs in the cardiovascular system drugs , it is originally and successfully developed by the US Bristol-Myers Squibb company , the trade name is Monopril, it was first listed in the UK in 1991, followed by a number of countries including the United States and European countries,it is used for the treatment of hypertension ,and for treatment of heart failure in combination with a diuretic. Fosinopril is a prodrug, after oral absorption,it is hydrolyzed in the gastrointestinal tract and liver to become a diacids complex complex, fosinopril sodium which has pharmacological activity and to play its role. It can competitively bind with ACE active ligand zinc ion , blocking angiotensin Ⅰ becoming into angiotensin Ⅱ, so that the blood vessels are dilate, aldosterone secretion is decreased, and blood pressure is decreased. Its ACE inhibition strength is similar to enalapril. Hypertension patients are treated with fosinopril ,the drug plays its role one hour after administration ,after 2 to 6 hours .it is up to maximum antihypertensive effect, it can hold effect for 24 hours, 1 times / day administration. Fosinopril can reduce peripheral vascular resistance, so that systemic vascular resistance is decreased, the cardiovascular output, left ventricular ejection fraction and left ventricular filling increase, thereby cardiac function is improved . The product also allows renal blood flow, glomerular filtration, plasma volume maintained or improved, renal vascular resistance is decreased, it does not affect cerebral blood flow. Oral bioavailability 36%, the concentration of blood Fosinoprilat reaches the peak 3 hours after the administration, t1 / 2 is 11.5 hours, and for hypertension associated with reduced renal function patients, when they take the drug, there is compensatory increase in hepatic metabolism, and when hypertension associated reduced liver function, renal function increases the elimination of the drug, due to the elimination of this compensatory mechanism, fosinopril treatment for high blood pressure,when it comes to that liver and kidney function is reduced, it is generally not necessary to adjust the dosage. First treatment of hypertension with the drug is an oral dose of 10mg / times, 1 time / day, general therapeutic dose range is 20 ~ 40mg / d. It can"in a lasting time and stably decrease blood pressure to protect heart and kidney , the dual elimination of kidney and liver is safer" because fosinopril sodium- does not have free thiol group, clinically, skin rashes and other allergic reactions caused by mercapto are less generated,it is the based medication for hypertension combined crown heart disease and chronic heart failure patients, it is also the preferred treatment of hypertension and diabetes patients , it is suitable for all strong indications of high blood pressure. Especially for the elderly and patients with liver and kidney dysfunction, the use of the product is more safe and convenient. The above information is edited by the chemicalbook of Tian Ye. |
| Chemical Properties | White to Off-White Crystalline Solid |
| Usage | A phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor. Antihypertensive. |
| Usage | A labelled phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor. |
| Usage | Fosinopril sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure. |
| Fosinopril sodium Preparation Products And Raw materials |
| Preparation Products | Fosinopril |