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CAS NO.86639-52-3
1(10-100)Metric Ton1(10-100)Metric Ton
| 7-Ethyl-10-hydroxycamptothecin Basic information |
| Product Name: | 7-Ethyl-10-hydroxycamptothecin |
| Synonyms: | CAMPTOTHECIN, 7-ETHYL-10-HYDROXY;4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;7-ETHYL-10-HYDROXYCAMPTOTHECIN;7-ETHYL-10-HYDROXYCAMPTOTHECINE;7-ETHYL-10-HYDROXY-CPT;SN38;10-dihydroxy-;4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4,7-diethyl-1h-pyrano(3 |
| CAS: | 86639-52-3 |
| MF: | C22H20N2O5 |
| MW: | 392.4 |
| EINECS: | |
| Product Categories: | Pharmaceutical Raw Materials;Miscellaneous Natural Products;Antitumors for Research and Experimental Use;Biochemistry;Natural Plant Extract;Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Natural Anti-cancer Medical Materials and It's Derivatives;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Inhibitors |
| Mol File: | 86639-52-3.mol |
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| 7-Ethyl-10-hydroxycamptothecin Chemical Properties |
| mp | 217 °C |
| refractive index | 21.5 ° (C=0.2, THF) |
| storage temp. | −20°C |
| CAS DataBase Reference | 86639-52-3(CAS DataBase Reference) |
| 7-Ethyl-10-hydroxycamptothecin Usage And Synthesis |
| Chemical Properties | Light-Yellow Solid |
| Usage | A metabolite of Irinotecan, a DNA topoisomerase inhibitor |
| Biological Activity | Active metabolite of CPT-11 that inhibits DNA topoisomerase I (IC 50 values are 0.74 and 1.9 μ M in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC 50 values are 0.077 and 1.3 μ M respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC 50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively). |
| 7-Ethyl-10-hydroxycamptothecin Preparation Products And Raw materials |
| Preparation Products | Irinotecan |
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