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Country: China (Mainland)
Business Type:Trading Company
Tel: +86-371- 86259723
Tel: 17734809689
Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
Mobile: 17734809689
Tel: +86-371- 86259723
Fax: +86-371- 86259723
Province/state: HENAN
City: ZHENGZHOU
Street: Mingmen International Center, NO.222 Dongming Road,Zhengzhou,Henan,China
MaxCard:
CAS NO.85622-93-1
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
About Service
1. Quality control, before shipment, free sample for test.
2. Prompt shipment with professional documents
3. Packing as your request, with photo before shipment
4. Mixed containers with different mixed items in one container
About Company
Product Name: | Temozolomide |
Synonyms: | 4-methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide;TEMOZOLOMIDE;1-d)(1,2,3,5)tetrazine-8-carboxamide,3,4-dihydro-3-methyl-4-oxo-imidazo(;3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide;3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide;8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3h)-one;ccrg81045;m&b39831 |
CAS: | 85622-93-1 |
MF: | C6H6N6O2 |
MW: | 194.15 |
EINECS: | |
Product Categories: | Active Pharmaceutical Ingredients;Antineoplastic;Intermediates & Fine Chemicals;Pharmaceuticals;Antitumour;Bases & Related Reagents;Heterocycles;Nucleotides;Displays antitumor activity.;API;TEMODAR;Inhibitors |
Mol File: | 85622-93-1.mol |
Temozolomide Chemical Properties |
mp | 212°C dec. |
storage temp. | 2-8°C |
CAS DataBase Reference | 85622-93-1(CAS DataBase Reference) |
Safety Information |
Hazard Codes | T,Xi |
Risk Statements | 45-46-60-61-22-36/37/38 |
Safety Statements | 24/25-45-36/37-26-53-36 |
RTECS | NJ5927050 |
Chemical Properties | It is crystallized from dichloromethane, m.p. 212 °C (decomposition). UV maximal absorption wavelength (95% ethanol): 327nm. |
Application | Antineoplastic agents. Spontaneous and rapid degradation and produce the active metabolite MTIC in vivo, yielding anti-tumor effect. |
Production methods | Amino-4-carboxamido-imidazole is first subject to nitrite diazotization, and has reaction with methyl isocyanate in dichloromethane for cyclization to obtain ammonium temozolomide. |
Chemical Properties | Off-White to Light-Pink Crystalline Solid |
Usage | Imidazotetrazine alkylating agent. An antineoplastic. |
Usage | inhibits cancer cells similar to paclitaxel effective against paclitaxel-resistant tumours |
Biological Activity | DNA methylating, chemotherapeutic agent. Displays antitumor activity against a board spectrum of tumors, including leukemias, lymphomas and solid tumors (IC 50 = 5.0 μ M for cytotoxicity against mouse TLX5 lymphoma cells). |
Temozolomide Preparation Products And Raw materials |
Raw materials | METHYLISOCYANATE 1 X 500MG NEAT-->5-Amino-4-imidazolecarboxamide |