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Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
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Tel: +86-371- 86259723
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CAS NO.84449-90-1
| Raloxifene Basic information |
| Product Name: | Raloxifene |
| Synonyms: | RALOXIFEN;RALOXIFENE;[4-[2-(1-Piperidinyl) Ethoxy] Phenyl]methanone.HCL;RALOXAFINE;[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone;[6-hydroxy-2-(4-hydroxyphenyl)benzothiophen-3-yl]-[4-[2-(1-piperidyl)ethoxy]phenyl]methanone hydrochloride;[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-y1][4-[2-(1-piperidinyl)ethoxy]phenyl]methamone;Evista |
| CAS: | 84449-90-1 |
| MF: | C28H27NO4S |
| MW: | 473.58 |
| EINECS: | |
| Product Categories: | Raloxifene;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate |
| Mol File: | 84449-90-1.mol |
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| Raloxifene Chemical Properties |
| Melting point | 250-253°C |
| storage temp. | Desiccate at +4°C |
| solubility | DMSO: 28 mg/mL, soluble |
| form | solid |
| color | light yellow |
| CAS DataBase Reference | 84449-90-1(CAS DataBase Reference) |
| Safety Information |
| WGK Germany | 3 |
| Hazardous Substances Data | 84449-90-1(Hazardous Substances Data) |
| Raloxifene Usage And Synthesis |
| Chemical Properties | Light-Yellow Solid |
| Usage | A nonsteroidal estrogen receptor mixed agonist/antagonist |
| Definition | ChEBI: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively. |
| Biological Activity | Selective estrogen receptor modulator (SERM) that binds to ER α and ER β , and tissue-dependently activates or blocks estrogen-induced transcription. Acts as an antiestrogen in breast and uterine tissue, but displays estrogen agonist activity in bone. In D12 rat hypothalamic cells, inhibits progesterone receptor induction by estrogen with an IC 50 of 1 nM. |
| Raloxifene Preparation Products And Raw materials |
| Raw materials | Methanesulfonyl chloride-->Biphenyl-->Thianaphthene-->2-Bromo-4'-methoxyacetophenone-->Phenetole |
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