HENAN SUNLAKE ENTERPRISE CORPORATION
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Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
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Tel: +86-371- 86259723
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CAS NO.83905-01-5
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
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About Company
| Product Name: | Azithromycin |
| Synonyms: | N-METHYL-11-AZA-10-DEOXO-10-DIHYDROERYTHROMYCIN A;11-(4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl)oxy-2-ethyl-3,4,10-tr;11-(4-DIMETHYLAMINO-3-HYDROXY-6-METHYL-TETRAHYDRO-PYRAN-2-YLOXY)-2-ETHYL-3,4,10-TRIHYDROXY-14-(5-HYDROXY-4-METHOXY-4,6-DIMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-3,5,6,8,10,12,13-HEPTAMETHYL-1-OXA-6-AZA-CYCLOPENTADECAN-15-ONE;9-DEOXO-9ALPHA-METHYL-9ALPHA-AZA-HOMOERYTHROMYCIN A;9-deoxo-9a-methyl-9a-aza-homoerythromycin a;AZITHROMYCIN;AZITHROMYCINE;1-oxa-6-azacyclopentadecan-15-one,13-((2,6-dideoxy-3-c-methyl-3-o-methyl-alpha |
| CAS: | 83905-01-5 |
| MF: | C38H72N2O12 |
| MW: | 748.98 |
| EINECS: | |
| Product Categories: | Antibiotics;Antibiotic;Antibiotic Explorer;Intermediates & Fine Chemicals;Pharmaceuticals;API's;NeatsMore...Close...;1694 Pharmaceuticals&Personal Care Products;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics A-FAntibiotics;AntiviralAntibiotics;Chemical Structure Class;Interferes with Protein SynthesisAntibiotics;MacrolidesEPA;Mechanism of Action;Spectrum of Activity;veterinary medicine,soluble powder,preparation;Peptide Synthesis/Antibiotics;Pharmaceutical intermediate;Inhibitors |
| Mol File: | 83905-01-5.mol |
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| Azithromycin Chemical Properties |
| mp | 113-115°C |
| storage temp. | Store at -20°C |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 83905-01-5(CAS DataBase Reference) |
| EPA Substance Registry System | 1-Oxa-6-azacyclopentadecan- 15-one, 13-[(2,6-dideoxy-3-C-methyl- 3-O-methyl-.alpha.-L-ribo- hexopyranosyl)oxy]-2-ethyl- 3,4,10-trihydroxy-3,5,6,8, 10,12,14-heptamethyl-11-[[ 3,4,6-trideoxy-3-(dimethylamino)-. beta.-D-xylo-hexopyranosyl] oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S, 13S,14R)-(83905-01-5) |
| Safety Information |
| Hazard Codes | Xi,Xn |
| Risk Statements | 42/43 |
| Safety Statements | 22-36/37-45 |
| RTECS | RN6960000 |
| Hazardous Substances Data | 83905-01-5(Hazardous Substances Data) |
| Chemical properties | White crystals. Melting point 113--115 ℃. [Α] D20-37 ° (C = 1, chloroform). |
| application | Macrolide antibiotic, 15-membered nitrogen-containing heterocyclic, antibacterial mechanism is similar to Erythromycin, but antibacterial spectrum is broader. The antibacterial activity of Gram-positive bacteria is stronger. As for Gram-negative bacteria such as Haemophilus influenzae, Salmonella, E. coli, Shigella bacteria, it have strong antibacterial activity. And it is acid stable and well tolerated. It has a very good therapeutic effect on respiratory tract infections, skin and soft tissue infections, sexually transmitted diseases which are caused by sensitive bacteria. |
| Production methods | Using Erythromycin A as raw material, after oximation, under the action of hydrochloric acid, Beckmann rearrangement is performed, followed by dehydration, reduction, methylation , and Azithromycin is obtained. |
| Chemical Properties | White Crystalline Powder |
| Usage | Labelled Azithromycin, a semi-synthetic macrolide antibiotic; related to Erythromycin A. Antibacterial. |
| Usage | Azithromycin is a semi-synthetic, ring-expanded erythromycin, produced by a Beckmann rearrangement of erythromycin oxime and reduction to the imine ether, followed by reductive methylation. Azithromycin was the first of the azalides and was designed to improve stability and biological half-life of erythromycin A, as well as improve activity against Gram negative bacteria. Since its discovery in 1980 by Djokic and co-workers, azithromycin has enjoyed considerable therapeutic success. |
| Usage | Cephalosporin antibiotic |
| Usage | Azithromycin is a semi-synthetic, ring-expanded erythromycin produced by a Beckmann rearrangement of erythromycin oxime and reduction to the imine ether, followed by reductive methylation. Azithromycin was the first of the azalides and was designed to improve the stability and biological half-life of erythromycin A, as well as improve activity against Gram negative bacteria. Since its discovery in 1980 by Djokic and co-workers, azithromycin has enjoyed considerable therapeutic success. |
| Usage | Labeled Azithromycin, Intended for use as an internal standard for the quantification of Azithromycin by GC- or LC-mass spectrometry |
| Biological Activity | Macrolide antibiotic. Inhibits 50S ribosomal subunit formation and elongation at transpeptidation step in gram-positive and gram-negative organisms. Orally active with improved pharmacokinetics over erythromycin in mouse models. |
| Azithromycin Preparation Products And Raw materials |
| Raw materials | Erythromycin |