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CAS NO.76-25-5
1(10-100)Gram1(100-200)Gram
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| Triamcinolone acetonide Basic information |
| Appearance and properties Glucocorticoid drugs Application Category Toxicity grading Acute toxicityFlammability hazard characteristics Storage Characteristics Extinguishing agent |
| Product Name: | Triamcinolone acetonide |
| Synonyms: | KENALOG;ARISTODERM;9ALPHA-FLUORO-11BETA,21-DIHYDROXY-16ALPHA,17-ISOPROPYLIDENEDIOXY-1,4-PREGNADIENE-3,20-DIONE;9ALPHA-FLUORO-16ALPHA-HYDROXYPREDNISOLONE 16ALPHA,17ALPHA-ACETONIDE;9ALPHA-FLUORO-11BETA,16ALPHA,17ALPHA,21-TETRAHYDROXY-1,4-PREGNADIENE-3,20-DIONE 16,17-ACETONIDE;9a-fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide;9a-fluoro-16a-hydroxyprednisolone 16a,17a-acetonide;ALPHA-FLUORO-11BETA,16ALPHA,17,21-TETRA-HYDROXYPREGNA-1,4-DIENE-3,20-DIONE |
| CAS: | 76-25-5 |
| MF: | C24H31FO6 |
| MW: | 434.5 |
| EINECS: | 200-948-7 |
| Product Categories: | Biochemistry;Steroids;Steroids (Others);Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;NASACORT |
| Mol File: | 76-25-5.mol |
|
|
|
| Triamcinolone acetonide Chemical Properties |
| mp | 274-278°C (dec.) |
| storage temp. | Refrigerator |
| Merck | 9596 |
| Stability: | Combustible. Incompatible with strong oxidizing agents. |
| NIST Chemistry Reference | Triamcinolone acetonide(76-25-5) |
| EPA Substance Registry System | Pregna-1,4-diene- 3,20-dione, 9-fluoro-11,21-dihydroxy-16, 17-[(1-methylethylidene)bis( oxy)]-, (11.beta.,16.alpha.)-(76-25-5) |
| Safety Information |
| Hazard Codes | T |
| Risk Statements | 61 |
| Safety Statements | 53-45 |
| WGK Germany | 3 |
| RTECS | TU3920000 |
| MSDS Information |
| Provider | Language |
|---|---|
| 9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide | English |
| SigmaAldrich | English |
| Triamcinolone acetonide Usage And Synthesis |
| Appearance and properties | Triamcinolone acetonide, its acetate form appears to be white or white-like crystalline powder. The drug is odorless, with bitter taste. It is hardly soluble in water, slightly soluble in ethanol, soluble in chloroform, and slightly soluble in acetone. |
| Glucocorticoid drugs |
Triamcinolone acetonide is a kind of long-term glucocorticoid drugs which is now widely used in clinical Dermatology of China. It belongs to adrenocorticotropic hormone drugs. It is the derivative of Triamcinolone, and with the same function as Triamcinolone. Triamcinolone acetonide functions in anti-inflammatory, anti-allergic, anti-itching and shrinking capillaries. What’s more, besides its weak water-sodium retention, the effect of Triamcinolone acetonide for anti-inflammatory, anti-allergic is much stronger and more durable than hydrocortisone (10 to 30 folds), and prednisone. It can also treat bronchial asthma by aerosol inhalation with very strong and durable effect. Triamcinolone acetonide has better efficacy on local treatment compared with triamcinolone. It is Oral absorbed easily. Taking orally 5mg of the drug yields a bioavailability of about 23%. Its plasma concentration reaches peak (105 ng/mL) within one hour with the half-life is being 2 hours; It has a slow intramuscular absorption rate which takes effect within hours, and gives maximal effect within 1 to 2 days. The effect can be maintained for 2 ~ 3 weeks; the absorption rate of intradermal and intra-articular injection of the drug is low, but has a long-lasting effect; generally the efficacy can be maintained for more than 1-2 week per injection. This product has a low binding rate with plasma albumin protein, and is metabolized into non-active product in the liver, kidneys and tissues which is then further excreted by the kidneys. It also has a long-lasting effect upon local injection. Moreover, topical ointments can also produce a good effect. Clinically triamcinolone acetonide is used for treatment of various skin diseases such as atopic dermatitis, contact dermatitis, seborrheic dermatitis, neurodermatitis, eczema, psoriasis, psoriasis, lichen planus and skin pruritus, as well as bronchial asthma, rheumatoid arthritis, acute sprains, chronic ache in back and legs, frozen shoulder, tenosynovitis, ophthalmic inflammation, oral mucosal congestion, erosion, ulcers, granulomatous cheilitis, and oral mucosa chronic infectious diseases, Furthermore, it can also be used for local injection treatment in keloid, cystic acne, discoid lupus erythematosus, alopecia areata and other small area of damages. Triamcinolone acetonide nasal spray can be used for the prevention and treatment of perennial, seasonal allergic rhinitis, and vasomotor rhinitis. Intra-articular injection of this drug can eliminate inflammation and pain, swelling or can alleviate, pain, stiffness and swelling feeling. The above information is edited by the Chemicalbook of Dai Xiongfeng. |
| Application | It is adrenal cortex hormones drugs used for treating diseases such as neurodermatitis, eczema, psoriasis, joint pain, and asthma. |
| Category | Toxic Substances. |
| Toxicity grading | Highly toxic. |
| Acute toxicity | Subcutaneous - rat LD50: 13.1 mg / kg; intraperitoneal - Mouse LD50: 105 mg / kg. |
| Flammability hazard characteristics | Combustible; combustion produces toxic fumes of fluoride. |
| Storage Characteristics | Treasury: ventilation, low-temperature and dry; store separately from food raw materials. |
| Extinguishing agent | Dry powder, foam, sand, carbon dioxide, water spray. |
| Chemical Properties | White Solid |
| Usage | A glucocorticoid, antiasthmatic (inhalant); antiallergic (nasal). |
| Usage | antiinflammatory |
Service we provideļ¼
1. Mixed container, we can mix different items in one container.
2. Quality control, before shipment, free sample for test. after shipment, keep sample for 3 years
3. Prompt shipment with professional documents
4. Packing as your request, with photo before shipment
| C6H6O2 |
| Triamcinolone acetonide Basic information |
| Appearance and properties Glucocorticoid drugs Application Category Toxicity grading Acute toxicityFlammability hazard characteristics Storage Characteristics Extinguishing agent |
| Product Name: | Triamcinolone acetonide |
| Synonyms: | KENALOG;ARISTODERM;9ALPHA-FLUORO-11BETA,21-DIHYDROXY-16ALPHA,17-ISOPROPYLIDENEDIOXY-1,4-PREGNADIENE-3,20-DIONE;9ALPHA-FLUORO-16ALPHA-HYDROXYPREDNISOLONE 16ALPHA,17ALPHA-ACETONIDE;9ALPHA-FLUORO-11BETA,16ALPHA,17ALPHA,21-TETRAHYDROXY-1,4-PREGNADIENE-3,20-DIONE 16,17-ACETONIDE;9a-fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide;9a-fluoro-16a-hydroxyprednisolone 16a,17a-acetonide;ALPHA-FLUORO-11BETA,16ALPHA,17,21-TETRA-HYDROXYPREGNA-1,4-DIENE-3,20-DIONE |
| CAS: | 76-25-5 |
| MF: | C24H31FO6 |
| MW: | 434.5 |
| EINECS: | 200-948-7 |
| Product Categories: | Biochemistry;Steroids;Steroids (Others);Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;NASACORT |
| Mol File: | 76-25-5.mol |
|
|
|
| Triamcinolone acetonide Chemical Properties |
| mp | 274-278°C (dec.) |
| storage temp. | Refrigerator |
| Merck | 9596 |
| Stability: | Combustible. Incompatible with strong oxidizing agents. |
| NIST Chemistry Reference | Triamcinolone acetonide(76-25-5) |
| EPA Substance Registry System | Pregna-1,4-diene- 3,20-dione, 9-fluoro-11,21-dihydroxy-16, 17-[(1-methylethylidene)bis( oxy)]-, (11.beta.,16.alpha.)-(76-25-5) |
| Safety Information |
| Hazard Codes | T |
| Risk Statements | 61 |
| Safety Statements | 53-45 |
| WGK Germany | 3 |
| RTECS | TU3920000 |
| MSDS Information |
| Provider | Language |
|---|---|
| 9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide | English |
| SigmaAldrich | English |
| Triamcinolone acetonide Usage And Synthesis |
| Appearance and properties | Triamcinolone acetonide, its acetate form appears to be white or white-like crystalline powder. The drug is odorless, with bitter taste. It is hardly soluble in water, slightly soluble in ethanol, soluble in chloroform, and slightly soluble in acetone. |
| Glucocorticoid drugs |
Triamcinolone acetonide is a kind of long-term glucocorticoid drugs which is now widely used in clinical Dermatology of China. It belongs to adrenocorticotropic hormone drugs. It is the derivative of Triamcinolone, and with the same function as Triamcinolone. Triamcinolone acetonide functions in anti-inflammatory, anti-allergic, anti-itching and shrinking capillaries. What’s more, besides its weak water-sodium retention, the effect of Triamcinolone acetonide for anti-inflammatory, anti-allergic is much stronger and more durable than hydrocortisone (10 to 30 folds), and prednisone. It can also treat bronchial asthma by aerosol inhalation with very strong and durable effect. Triamcinolone acetonide has better efficacy on local treatment compared with triamcinolone. It is Oral absorbed easily. Taking orally 5mg of the drug yields a bioavailability of about 23%. Its plasma concentration reaches peak (105 ng/mL) within one hour with the half-life is being 2 hours; It has a slow intramuscular absorption rate which takes effect within hours, and gives maximal effect within 1 to 2 days. The effect can be maintained for 2 ~ 3 weeks; the absorption rate of intradermal and intra-articular injection of the drug is low, but has a long-lasting effect; generally the efficacy can be maintained for more than 1-2 week per injection. This product has a low binding rate with plasma albumin protein, and is metabolized into non-active product in the liver, kidneys and tissues which is then further excreted by the kidneys. It also has a long-lasting effect upon local injection. Moreover, topical ointments can also produce a good effect. Clinically triamcinolone acetonide is used for treatment of various skin diseases such as atopic dermatitis, contact dermatitis, seborrheic dermatitis, neurodermatitis, eczema, psoriasis, psoriasis, lichen planus and skin pruritus, as well as bronchial asthma, rheumatoid arthritis, acute sprains, chronic ache in back and legs, frozen shoulder, tenosynovitis, ophthalmic inflammation, oral mucosal congestion, erosion, ulcers, granulomatous cheilitis, and oral mucosa chronic infectious diseases, Furthermore, it can also be used for local injection treatment in keloid, cystic acne, discoid lupus erythematosus, alopecia areata and other small area of damages. Triamcinolone acetonide nasal spray can be used for the prevention and treatment of perennial, seasonal allergic rhinitis, and vasomotor rhinitis. Intra-articular injection of this drug can eliminate inflammation and pain, swelling or can alleviate, pain, stiffness and swelling feeling. The above information is edited by the Chemicalbook of Dai Xiongfeng. |
| Application | It is adrenal cortex hormones drugs used for treating diseases such as neurodermatitis, eczema, psoriasis, joint pain, and asthma. |
| Category | Toxic Substances. |
| Toxicity grading | Highly toxic. |
| Acute toxicity | Subcutaneous - rat LD50: 13.1 mg / kg; intraperitoneal - Mouse LD50: 105 mg / kg. |
| Flammability hazard characteristics | Combustible; combustion produces toxic fumes of fluoride. |
| Storage Characteristics | Treasury: ventilation, low-temperature and dry; store separately from food raw materials. |
| Extinguishing agent | Dry powder, foam, sand, carbon dioxide, water spray. |
| Chemical Properties | White Solid |
| Usage | A glucocorticoid, antiasthmatic (inhalant); antiallergic (nasal). |
| Usage | antiinflammatory |