Product Certification&
Enterprise Certification
Country: China (Mainland)
Business Type:Trading Company
Tel: +86-371- 86259723
Tel: 17734809689
Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
Mobile: 17734809689
Tel: +86-371- 86259723
Fax: +86-371- 86259723
Province/state: HENAN
City: ZHENGZHOU
Street: Mingmen International Center, NO.222 Dongming Road,Zhengzhou,Henan,China
MaxCard:
Our Advantages
1, Any inquiry about chemicals will be welome and replied within 24 hours;
2, Competitive price;
3, Good quality is guaranteed;
4, Fast and safe delivery;
5, Full experience in manufacture and international trade;
6, Perfect and professional service.
Product information
Leflunomide Basic information |
Product Name: | Leflunomide |
Synonyms: | LEFLUNOMIDE;HWA 486;ALPHA,ALPHA,ALPHA-TRIFLUORO-5-METHYL-4-ISOXAZOLECARBOXY-P-TOLUIDIDE;5-METHYLISOXAZOLE-4-(4-TRIFLUOROMETHYLCARBOXANILIDE);5-METHYL-N-[4-(TRIFLUOROMETHYL)PHENYL]-4-ISOXAZOLECARBOXAMIDE;N-(4-TRIFLUOROMETHYLPHENYL)-5-METHYLISOXAZOL-4-CARBOXAMIDE;5-methylisoxazole-4-carboxylicacid(4-trifluoromethyl)anilide;5-methyl-n-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamid |
CAS: | 75706-12-6 |
MF: | C12H9F3N2O2 |
MW: | 270.21 |
EINECS: | |
Product Categories: | Active Pharmaceutical Ingredients;API;Osteoarthritis and Rheumatoid Arthritis;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Cytokine signaling;Aromatics;Heterocycles;An immunosuppressive agent;CARDENE;Other APIs |
Mol File: | 75706-12-6.mol |
Leflunomide Chemical Properties |
mp | 163-168°C |
storage temp. | 2-8°C |
CAS DataBase Reference | 75706-12-6(CAS DataBase Reference) |
Safety Information |
Hazard Codes | Xn,Xi |
Risk Statements | 22-36/37/38 |
Safety Statements | 26-36 |
RIDADR | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | NY2354200 |
Hazardous Substances Data | 75706-12-6(Hazardous Substances Data) |
MSDS Information |
Provider | Language |
---|---|
Leflunomide | English |
SigmaAldrich | English |
Leflunomide Usage And Synthesis |
Chemical Properties | Off White Crystalline Solid |
Usage | An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutical |
Usage | vasodilator |
Usage | anti-Altzheimer therapeutic |
Biological Activity | Immunosuppressant agent. In vitro the active metabolite A77 1726 (RS-61980) inhibits dihydroorotate dehydrogenase (K i = 2.7 μ M) and de novo pyrimidine synthesis in T-cells; blocks lymphocyte cell cycle progression and proliferation. A77 1726 also inhibits anti-CD3/CD28-induced cytokine production in PBMC cells (IC 50 = 21-27 μ g/ml). In vivo reduces inflammation in several animal models of autoimmune disease, arthritis, asthma and graft rejection. |
Henan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.
We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.
We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.
We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate.