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745-65-3 C20H34O5 Prostaglandin E1

CAS NO.745-65-3

  • Min.Order: 1 Kilogram
  • Payment Terms: L/C,D/A,D/P,T/T,
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Product Details

Keywords

  • 15-dihydroxy-9-oxo
  • 5-oxocyclopentaneheptanoicacid
  • 5-OXO-CYCLOPENTANEHEPTANOIC ACID

Quick Details

  • ProName: 745-65-3 C20H34O5 Prostaglandin E1
  • CasNo: 745-65-3
  • Molecular Formula: C20H34O5
  • Appearance: Crystalline Solid
  • Application: 745-65-3 ...
  • DeliveryTime: 7-10 days after payment
  • PackAge: As required
  • Port: Shanghai/Tianjin/Qingdao
  • ProductionCapacity: 100-200 Kilogram/Month
  • Purity: 99%
  • Storage: -20°C
  • Transportation: By air/sea/express
  • LimitNum: 1 Kilogram
  • Grade: Pharma Grade

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About Certificate

 

1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)

 

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HenNan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
     Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs ,  Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East ,  Africa , South America and some other countries and areas.
    We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you  better with our high - quality products and professional team.
    We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.
     We  welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!

Details

Product Name: Prostaglandin E1
Synonyms: (-)-protaglandine1;11,15-dihydroxy-9-oxo-,(11-alpha,13e,15s)-prost-13-en-1-oicaci;l-3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentaneheptanoicacid;l-cyclopentaneheptanoicaci;l-pge1;l-protaglandine1;3-HYDROXY-2-(3-HYDROXY-1-OCTENYL)-5-OXO-CYCLOPENTANEHEPTANOIC ACID;ALPROSTADIL
CAS: 745-65-3
MF: C20H34O5
MW: 354.48
EINECS: 212-017-2
Product Categories: Miscellaneous Biochemicals;Prostaglandins;Prostaglandin;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Prostanoid receptor and related;Prostaglandin E1, Edex, Muse, Liprostin
Mol File: 745-65-3.mol
Prostaglandin E1 Structure
 
Prostaglandin E1 Chemical Properties
mp  115-116 °C
alpha  -64 º (c=1.0, C2H5OH)
storage temp.  −20°C
solubility  ethanol: 1 mg/mL
form  powder
Water Solubility  insoluble
Merck  13,7968
 
Safety Information
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38-61
Safety Statements  36-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  GY4569800
F  8-10
HazardClass  6.1(b)
PackingGroup  III
HS Code  29375000
Chemical Properties Crystalline Solid
Production method Sheep seminal vesicles were uesd as raw material for the preparation of PGE crude , with enzyme preparation, incubation, organic solvent extraction, silica gel column separation.
The preparation of PGE crude: sheep seminal vesicles [KCl, EDTANa2, PH8] → enzyme suspension [hydroquinone, glutathione] → [arachidonic acid, O2] reaction solution [acetone, ether, methylene chloride] → PGS crude [Separation] → [silica gel] PGE crude Preparation PGE1 finished product: per 1g PGE crude product used 20g silica gel, 10 times the mass of PGE activated silver nitrate silica gel from 200-250 mesh was suspended in expansion agents including: V ethyl acetate : V acetic acid: V petroleum ether: V water = 220: 22.5: 125 : 5 (bp of petroleum ether is 90-120 ℃) , with wet packed column. A small amount of the crude product was dissolved in the same expansion agents, put in the column , eluted. PGE1 and PGE2 were collected . The PGE1 part was put below 35 ℃ to nitrogen concentrating until acetic acid odor was removed, ethyl acetate was added to dissolve, added acid to wash, pH4-5, saline was added to remove silver. The ethyl acetate solution was set in the refrigerator overnight to get finished PGE1 .
Usage A primary Prostaglandin; easily crystallized from purified biological extracts. Vasodilator (peripheral)
Usage Vasodilator;Prostaglandin receptor agonist
Biological Activity Prostaglandin with some selectivity for EP 3 and EP 4 receptors (K i values are 1.1, 2.1, 36, 10 and 33 nM for mouse EP 3 , EP 4 , EP 1 , EP 2 and IP receptors respectively). Inhibits platelet aggregation and is a vasodilator in vivo .
 
Prostaglandin E1 Preparation Products And Raw materials
Raw materials Hydrogen-->Silver nitrate-->2-N-BUTOXYETHYL METHACRYLATE-->Cyclopentene-->Arachidonic acid-->Prostaglandin E2 -->GAMMA-LINOLENIC ACID METHYL ESTER-->Glutathione

 

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