HENAN SUNLAKE ENTERPRISE CORPORATION
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Tel: 17734809689
Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
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Tel: +86-371- 86259723
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CAS NO.67-52-7
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
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About Company
| Product Name: | Barbituric acid |
| Synonyms: | SPECS AG-670/31547005;TIMTEC-BB SBB004242;PYRIMIDINE TRIONE;N,N'-MALONYLUREA;2,4,6-Pyrimidinetriol;2,4,6-pyrimidinetrione;2,4,6-Pyrimidinetrione(1H,3H,5H);2,4,6-Trioxohexahydropyrimidine |
| CAS: | 67-52-7 |
| MF: | C4H4N2O3 |
| MW: | 128.09 |
| EINECS: | 200-658-0 |
| Product Categories: | Pharmaceutical Intermediates;PYRIMIDINE;Miscellaneous Biochemicals;Pyrimidine series;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Heterocycle-Pyrimidine series |
| Mol File: | 67-52-7.mol |
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| Barbituric acid Chemical Properties |
| mp | 248-252 °C (dec.)(lit.) |
| bp | 260℃ （分解） |
| Fp | 150 °C |
| Water Solubility | 142 g/L (20 ºC) |
| Merck | 14,963 |
| BRN | 120502 |
| CAS DataBase Reference | 67-52-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Barbituric acid(67-52-7) |
| EPA Substance Registry System | 2,4,6(1H,3H,5H)- Pyrimidinetrione(67-52-7) |
| Chemical Properties | White crystalline powder. Odorless. Soluble in water and ether, insoluble in water and alcohol. |
| Application | It is used for intermediate of organic synthesis raw materials, pharmaceuticals, plastics and dyes. It Is the intermediate of phenobarbital, vitamin B12 and other drugs,it is also used as a polymerization catalyst and the preparation of benzimidazolone-based organic pigments. Also it is used as colorimetric determination of uronic and pentosan reagents. |
| production method | It is derived By the reaction of diethyl malonate and urea. First put Urea in a reaction tank containing methanol ,heat , reflux , dissolve, then add the dried diethyl malonate and sodium methoxide, the reaction is refluxed at 66-68 ℃ for 4-5h, after distillation to recover methanol, cooling to 40-50 ℃, add dilute hydrochloric acid to adjust to pH 1-2.Cool to room temperature, throw to obtain crude, wash with distilled water once, dry to get crude , and then purify with water and activated carbon, dry to obtain products. Industrial barbituric acid is white or pink crystalline powder, strongly acidic, more than 98% content, melting point ≥245 ℃. Material consumption fixed: diethyl malonate 1098kg / t, urea 476kg / t, hydrochloric acid (reagent grade Ⅲ) 681kg / t, sodium methanol (28%) 369kg / t, methanol 1025kg / t. |
| Category | Flammable liquid |
| Toxicity grading | Middle toxic |
| Acute toxicity | oral- rat LD50:> 5000 mg / kg; intraperitoneal - Mouse LD50: 505 mg / kg |
| Explosive hazardous characteristics | allergic effect |
| Flammability hazard characteristics | Easily flammable; burning produces toxic nitrogen oxide fumes; people taking has no hypnotic effect |
| Storage Characteristics | Ventilated, low-temperature ,dry |
| extinguishing agent | Dry powder , foam, sand, carbon dioxide, water spray |
| Chemical Properties | CREAM COLOURED FINE CRYSTALLINE POWDER |
| Usage | Barbituric acid is a parent compound of barbiturate drugs. Unsubstituted barbituric acid has no hypnotic properties. |
| Barbituric acid Preparation Products And Raw materials |