Product Certification&
Enterprise Certification
Country: China (Mainland)
Business Type:Trading Company
Tel: +86-371- 86259723
Tel: 17734809689
Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
Mobile: 17734809689
Tel: +86-371- 86259723
Fax: +86-371- 86259723
Province/state: HENAN
City: ZHENGZHOU
Street: Mingmen International Center, NO.222 Dongming Road,Zhengzhou,Henan,China
MaxCard:
CAS NO.65141-46-0
Nicorandil Basic information |
Product Name: | Nicorandil |
Synonyms: | n-[2-(nitroxy)ethyl]-3-pyridinecarboxamide;N-[2-(NITROOXY)ETHYL]-3-PYRIDINECARBOXAMIDE;NICORANDIL;PERISALOL;SIGMART;IKOREL;ADANCOR;2-nicotinamidoethylnitrate |
CAS: | 65141-46-0 |
MF: | C8H9N3O4 |
MW: | 211.17 |
EINECS: | 265-514-1 |
Product Categories: | Pharmaceutical;Intermediates & Fine Chemicals;Pharmaceuticals;Potassium channel;Aromatics;Heterocycles;Ikorel;reagent;Cardiovascular APIs |
Mol File: | 65141-46-0.mol |
Nicorandil Chemical Properties |
mp | 92°C |
storage temp. | Desiccate at +4°C |
Nicorandil Usage And Synthesis |
Chemical Properties | White solid |
Usage | An antianginal |
Usage | Antihypertensor |
Biological Activity | K ATP channel opener and NO donor, clinically used as antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing K ATP channels (EC 50 values are 10 and > 500 mM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning. |
Nicorandil Preparation Products And Raw materials |
Raw materials | Nitric acid-->Ethanolamine-->2-N-BUTOXYETHYL METHACRYLATE-->Methyl nicotinate-->NICOTINOYL CHLORIDE HYDROCHLORIDE |
Products Name: |
Nicorandil |
Structural Formula: |
|
Chemical Name: |
|
Molecular Formula : |
C8H9N3O4 |
Molecular weight: |
211.18 |
CAS No.: |
65141-46-0 |
Specifications: |
BP/EP/USP/CP |
Use: |
White to whitish needle crystal powder, antianginal drugs |