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CAS NO.6284-40-8
| Meglumine Basic information |
| Product Name: | Meglumine |
| Synonyms: | N-Methyl-D-Glu;METHYL GLUCAMINE MEGLUMINE;MEGLUMINE, USP;N-Methylglucamine (Meglumine);N-Methyl-D-Glucamine>99%;MeglumineAntimoniateBase;N-METHYL-D-GLUCANINE;MEGLUMINE(N-METHYLGLUCAMINE) |
| CAS: | 6284-40-8 |
| MF: | C7H17NO5 |
| MW: | 195.21 |
| EINECS: | 228-506-9 |
| Product Categories: | Anilines, Aromatic Amines and Nitro Compounds;Aminosugars;Diagnostic agents;Biochemistry;Sugars;PREDEF;-;API |
| Mol File: | 6284-40-8.mol |
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|
|
| Meglumine Chemical Properties |
| Melting point | 129-131.5 °C(lit.) |
| alpha | -16.5 º (c=10, H2O, on dry sub) |
| Boiling point | 331.88°C (rough estimate) |
| density | 1.2669 (rough estimate) |
| refractive index | -16.5 ° (C=2, H2O) |
| RTECS | LZ4295770 |
| storage temp. | Store below +30°C. |
| solubility | H2O: 0.1 g/mL, clear, colorless |
| form | Crystalline Powder |
| pka | pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate) |
| color | White to almost white |
| PH | 11 (10g/l, H2O, 20℃) |
| optical activity | [α]20/D 16.5±0.5°, c = 2% in H2O |
| Water Solubility | 100 g/100 mL (25 ºC) |
| Sensitive | Air Sensitive & Hygroscopic |
| Merck | 14,6078 |
| BRN | 385906 |
| InChIKey | MBBZMMPHUWSWHV-VZFHVOOUSA-N |
| NIST Chemistry Reference | N-methylglucamine(6284-40-8) |
| EPA Substance Registry System | D-Glucitol, 1-deoxy-1-(methylamino)-(6284-40-8) |
| Safety Information |
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| F | 3-10-23 |
| Autoignition Temperature | ~662 °F |
| TSCA | Yes |
| HS Code | 29221980 |
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg |
| MSDS Information |
| Provider | Language |
|---|---|
| Meglumine | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| Meglumine Usage And Synthesis |
| Chemical Properties | white to almost white crystalline powder |
| Chemical Properties | Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor. |
| Uses | antiinflammatory |
| Uses | excipient in cosmetics and X-ray contrast media |
| Definition | ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis. |
| Production Methods | Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation. |
| Brand name | Renovue (Bracco). |
| Pharmaceutical Applications | Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media. |
| Safety |
Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient. LD50 (mouse, IP): 1.68 g/kg |
| storage |
Meglumine does not polymerize or dehydrate unless heated above 150°C for prolonged periods. The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended. |
| Purification Methods | Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.] |
| Incompatibilities | Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide. |
| Regulatory Status | Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK. |
| Meglumine Preparation Products And Raw materials |
| Raw materials | ACETALDEHYDE AMMONIA-->1-Glucose-methylamine schiffbase |
| Meglumine Basic information |
| Product Name: | Meglumine |
| Synonyms: | N-Methyl-D-Glu;METHYL GLUCAMINE MEGLUMINE;MEGLUMINE, USP;N-Methylglucamine (Meglumine);N-Methyl-D-Glucamine>99%;MeglumineAntimoniateBase;N-METHYL-D-GLUCANINE;MEGLUMINE(N-METHYLGLUCAMINE) |
| CAS: | 6284-40-8 |
| MF: | C7H17NO5 |
| MW: | 195.21 |
| EINECS: | 228-506-9 |
| Product Categories: | Anilines, Aromatic Amines and Nitro Compounds;Aminosugars;Diagnostic agents;Biochemistry;Sugars;PREDEF;-;API |
| Mol File: | 6284-40-8.mol |
|
|
|
| Meglumine Chemical Properties |
| Melting point | 129-131.5 °C(lit.) |
| alpha | -16.5 º (c=10, H2O, on dry sub) |
| Boiling point | 331.88°C (rough estimate) |
| density | 1.2669 (rough estimate) |
| refractive index | -16.5 ° (C=2, H2O) |
| RTECS | LZ4295770 |
| storage temp. | Store below +30°C. |
| solubility | H2O: 0.1 g/mL, clear, colorless |
| form | Crystalline Powder |
| pka | pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate) |
| color | White to almost white |
| PH | 11 (10g/l, H2O, 20℃) |
| optical activity | [α]20/D 16.5±0.5°, c = 2% in H2O |
| Water Solubility | 100 g/100 mL (25 ºC) |
| Sensitive | Air Sensitive & Hygroscopic |
| Merck | 14,6078 |
| BRN | 385906 |
| InChIKey | MBBZMMPHUWSWHV-VZFHVOOUSA-N |
| NIST Chemistry Reference | N-methylglucamine(6284-40-8) |
| EPA Substance Registry System | D-Glucitol, 1-deoxy-1-(methylamino)-(6284-40-8) |
| Safety Information |
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| F | 3-10-23 |
| Autoignition Temperature | ~662 °F |
| TSCA | Yes |
| HS Code | 29221980 |
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg |
| MSDS Information |
| Provider | Language |
|---|---|
| Meglumine | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| Meglumine Usage And Synthesis |
| Chemical Properties | white to almost white crystalline powder |
| Chemical Properties | Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor. |
| Uses | antiinflammatory |
| Uses | excipient in cosmetics and X-ray contrast media |
| Definition | ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis. |
| Production Methods | Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation. |
| Brand name | Renovue (Bracco). |
| Pharmaceutical Applications | Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media. |
| Safety |
Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient. LD50 (mouse, IP): 1.68 g/kg |
| storage |
Meglumine does not polymerize or dehydrate unless heated above 150°C for prolonged periods. The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended. |
| Purification Methods | Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.] |
| Incompatibilities | Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide. |
| Regulatory Status | Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK. |
| Meglumine Preparation Products And Raw materials |
| Raw materials | ACETALDEHYDE AMMONIA-->1-Glucose-methylamine schiffbase |