Keywords

• (S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
• 608141-41-9 supplier
• 608141-41-9 price

Quick Details

• ProName: Apremilast
• CasNo: 608141-41-9
• Molecular Formula: C22H24N2O7S
• Appearance: Light yellow to off-white powder
• Application: Pharmaceutical
• DeliveryTime: Within 7 working days
• PackAge: 500g...1kg...more
• Port: Shanghai Port
• ProductionCapacity: 50-60 Kilogram/Month
• Purity: 99% Min
• Storage: Protected from light, stored hermetica...
• Transportation: By air
• LimitNum: 500 Gram
• Grade: Pharma Grade
• Molecular Weight: 460.50

Superiority

HENAN SUNLAKE ENTERPRISE CORPORATION

Our company advantages:

1. The highest quality with the competitive price.

2. Professional human services.

3. The fastest and safest delivery service.

4. The faster and safest delivery service.

5. The high purity products.

6. We have a sufficient supply of stock.

7. A variety of payments, such as L/C, TT, , MoneyGram or other payments.

Details

Apremilast (CC-10004) Basic information

Description Uses Metabolism and Drug interaction safety information side effects References

Product Name:	Apremilast (CC-10004)
Synonyms:	ApreMilast;(S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione;(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide;ApreMilast,CC-10004;AcetaMide, N-[2-[(1S)-1-(3-ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;Appleton West;(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide Apremilast (CC-10004;(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)
CAS:	608141-41-9
MF:	C22H24N2O7S
MW:	0
EINECS:	-0
Product Categories:	Inhibitor;Inhibitors;Other series
Mol File:	Mol File

Apremilast (CC-10004) Chemical Properties

density

1.381

Safety Information

MSDS Information

 

Apremilast (CC-10004) Usage And Synthesis

Description	Apremilast (Otezla) was approved by the FDA on March 21, 2014 for the treatment of adult patients with active psoriatic arthritis. Apremilast is a member of a new class of oral small molecule inhibitors of the phosphosphodiesterase 4 (PDE4) enzyme. When PDE4 is inhibited in immune cells, it results in elevation of intracellular cyclic adenosine monophosphate (cAMP) levels, which can regulate inflammatory mediators. The current clinical data indicate that apremilast is an effective and well tolerated option for the management of psoriasis and PsA in adults.
Uses	Treating active psoriatic arthritis. It is also used to treat moderate to severe plaque psoriasis in certain patients.
Metabolism and Drug interaction	Oral administration of apremilast has an absolute biovailability of 73% with peak concentration at 2.5 hours (Tmax). The half-life of apremilast is 6-9 hours. Apremilast is metabolized by the both cytochrome (CYP) and non-CYP pathways. In vitro studies have demonstrated that apremilast metabolism is primarily mediated by the CYP3A4 pathway. Thus, concomitant use of apremilast with CYP450 enzyme inducers (such as rifampin, phenobarbital, carbamazepine, phenytoin) is not recommended. There are no significant drug-drug interactions with oral contraceptives, ketoconazole, or methotrexate.
safety information	1.Apremilast may cause depression. The risk may be greater in patients who have a history of depression or suicidal thoughts or actions. Families and caregivers must closely watch patients who take apremilast. It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has new, worsened, or sudden symptoms, such as depression; anxiety, restlessness, or irritability; panic attacks; or any changes in behavior. Contact the doctor right away if any signs of suicidal thoughts or actions occur. 2.Apremilast may cause weight loss. You will need to have regular weight checks while you are taking apremilast.
side effects	Diarrhea; headache; nausea; weight loss.
References	1. # 2. # 3. # 4. #

Company Information

Henan Sunlake Enterprise Corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion. The com[any was established in june. 1998, until now having more than 18 years experience in manufacturing & exporting chemical raw material .

Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others. These products have been being well exported to europe, southeast Asia, the Middle East ,Africa, South America and some other countries and areas.

We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team. We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional supplier in international market.

We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!