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CAS NO.6055-19-2
1(10-100)Kilogram1(100-500)Kilogram2(500-1000)Kilogram
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| Cyclophosphamide monohydrate Basic information |
| Product Name: | Cyclophosphamide monohydrate |
| Synonyms: | (bis(chloro-2-ethyl)amino)-2-tetrahydro-3,4,5,6-oxazaphosphorine-1,3,2-oxide;1-bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridinemonohydrate;2-(bis(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphocyclohexane2-oxidemonohydr;2-(di(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphacyclohexane-2-oxidemonohydra;2h-1,3,2-oxazaphosphorine,tetrahydro-2-(bis(2-chloroethyl)amino)-,2-oxide,mo;-2monohydrate;cyclicn’,o-propyleneesterofn,n-bis(2-chloroethyl)phosphorodiamidicacidm;endoxanmonohydrate |
| CAS: | 6055-19-2 |
| MF: | C7H17Cl2N2O3P |
| MW: | 279.1 |
| EINECS: | 200-015-4 |
| Product Categories: | Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Intermediates & Fine Chemicals;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;CYTOXAN;Anti-cancer&immunity |
| Mol File: | 6055-19-2.mol |
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| Cyclophosphamide monohydrate Chemical Properties |
| mp | 49-51 °C(lit.) |
| Fp | >230 °F |
| storage temp. | 2-8°C |
| solubility | H2O: 0.1 g/mL, clear, colorless |
| Water Solubility | 40 g/L |
| Merck | 14,2747 |
| BRN | 8167897 |
| CAS DataBase Reference | 6055-19-2(CAS DataBase Reference) |
| EPA Substance Registry System | 2H-1,3,2-Oxazaphosphorin- 2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide, monohydrate(6055-19-2) |
| Safety Information |
| Hazard Codes | T |
| Risk Statements | 45-25-61-46-36/37/38-23/24/25 |
| Safety Statements | 53-45-37/39-26 |
| RIDADR | UN 3464 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | RP6157750 |
| F | 10 |
| HazardClass | 6.1 |
| PackingGroup | II |
| MSDS Information |
| Provider | Language |
|---|---|
| N,N-Bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester amide monohydrate | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| Cyclophosphamide monohydrate Usage And Synthesis |
| Chemical Properties | White to Off-White Solid |
| Usage | It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen. |
| Usage | antineoplastic, alkylating agent |
| Usage | alkylating agent in cancer therapy |
| General Description | Fine white crystalline powder with a slightly bitter taste. Little or no odor. |
| Air & Water Reactions | Water soluble. Sensitive to moisture and light. Aqueous solutions may be kept for a few hours above room temperature, but hydrolysis occurs at temperatures above 86°F. Cyclophosphamide monohydrate undergoes both specific acid and specific base catalysis at extreme pHs. Spontaneous hydrolysis in aqueous solutions. |
| Reactivity Profile | Polymerization can occur at temperatures > 120° F. Cyclophosphamide monohydrate reacts with strong oxidizing agents, strong acids and strong bases. Benzyl alcohol increases rate of hydrolysis. |
| Fire Hazard | Cyclophosphamide monohydrate is probably combustible. |
| Cyclophosphamide monohydrate Preparation Products And Raw materials |
| Raw materials | 2,2'-Iminodiethanol |