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CAS NO.60-56-0
| Methimazole Basic information |
| Imidazole anti-thyroid drugs Chemical properties Application Production methods |
| Product Name: | Methimazole |
| Synonyms: | TAPAZOLE;THIAMAZOLE;1,3-dihydro-1-methyl-2h-imidazole-2-thion;1,3-dihydro-1-methyl-2H-Imidazole-2-thione;1-methyl-2-mercapto-imidazol;1-methyl-imidazole-2-thio;1-Metylo 2 merkaptoimidazolem;1-metylo2merkaptoimidazolem |
| CAS: | 60-56-0 |
| MF: | C4H6N2S |
| MW: | 114.17 |
| EINECS: | 200-482-4 |
| Product Categories: | Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Bioactive Small Molecules;Building Blocks;Cell Biology;Chemical Synthesis;Heterocyclic Building Blocks;Imidazoles;M;API;TAPAZOLE;Other APIs;Medicine Intermediates |
| Mol File: | 60-56-0.mol |
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| Methimazole Chemical Properties |
| mp | 144-147 °C(lit.) |
| bp | 280 °C |
| Fp | 280°C |
| storage temp. | Refrigerator |
| Water Solubility | soluble |
| Merck | 14,5971 |
| BRN | 108646 |
| CAS DataBase Reference | 60-56-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Methimazole(60-56-0) |
| EPA Substance Registry System | 2H-Imidazole-2-thione, 1,3-dihydro-1-methyl-(60-56-0) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 43-62-63-22 |
| Safety Statements | 26-27-36-45-36/37 |
| WGK Germany | 3 |
| RTECS | NI8615000 |
| HS Code | 29332990 |
| Hazardous Substances Data | 60-56-0(Hazardous Substances Data) |
| MSDS Information |
| Provider | Language |
|---|---|
| Methimazole | English |
| ACROS | English |
| SigmaAldrich | English |
| ALFA | English |
| Methimazole Usage And Synthesis |
| Imidazole anti-thyroid drugs |
Methimazole is an imidazole anti-thyroid drug, not a hormone drug, the commodity on the market is known as methylthio thiazole, it is primarily used for the treatment of hyperthyroidism, by inhibiting the peroxidase system, hindering thyroxine (T4) and tri-triiodothyronine (T3) synthesis, animal experiments show that it can inhibit B lymphocytes synthesizing antibodies, and reduce levels of thyroid stimulating antibodies in blood circulating it can make suppressing T cell function return to normal, it is applicable to hyperthyroidism caused by a variety of factors . Like other various drugs (propylthiouracil), it also has some adverse reactions while it is taken, Including hematologic adverse reactions, primarily neutropenia, hematopoietic dysfunction or disorder, thrombocytopenia, reduction of prothrombin or factor VII ; long-term medication can also cause liver damage,such as cholestatic jaundice and toxic hepatitis ; other skin reactions such as hair loss, itching, rash, dermatitis, lupus erythematosus, as well as some other rare adverse reactions. Also methimazole allows prothrombin time to prolong , and increases serum alkaline phosphatase, aspartate aminotransferase (AST) and alanine aminotransferase (ALT)and causes blood bilirubin and blood lactate dehydrogenase increasing. Therefore, patients in the medication should regularly take blood tests, liver function tests and peripheral blood leukocytes. The above information is edited by the Chemicalbook of Tian Ye. |
| Chemical properties | leaf-shaped crystalline (ethanol), melting point 146-148 ℃, boiling point 280 ℃ (decomposition), soluble in water, soluble in alcohol, chloroform, slightly soluble in ether, benzene. |
| Application |
Carbimazole intermediates. anti-thyroid drugs. |
| Production methods | React amino acetal with methyl isothiocyanate to genarate this product. The product can also be produced from thiocyanate and N- substituted amino acetal. |
| Chemical Properties | White Solid |
| Usage | Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid |
| Methimazole Preparation Products And Raw materials |
| Raw materials | METHYLAMINE-->Potassium thiocyanate-->Methyl isothiocyanate-->2,2-Diethoxyethylamine |
| Chemical Name: | Methimazole |
| Cas No.: | 60-56-0 |
| Molecular Formula: | C4H6N2S |
| Molecular Weight: | 114.16 |
| Specification: | 99% |
| Molecular Structure: |
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