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CAS NO.58970-76-6
1(10-100)Metric Ton1(10-100)Metric Ton
| Ubenimex Basic information |
| Product Name: | Ubenimex |
| Synonyms: | 3-(r)-amino-2-(s)-hydroxy-4-phenylbutanoyl-(s)-leucine;n-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-,(s-(r*,s*))-l-leucin;nk421;UBENIMEX;N-[(2S,3R)-3-AMINO-2-HYDROXY-1-OXO-4-PHENYLBUTYL]-L-LEUCINE;N-((2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL)-L-LEUCINE;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL]-L-LEUCINE;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-LEU |
| CAS: | 58970-76-6 |
| MF: | C16H24N2O4 |
| MW: | 308.37 |
| EINECS: | 261-529-2 |
| Product Categories: | Active Pharmaceutical Ingredients;Ubenimex;Pepetides;ProteaseInhibitors;peptides;Bestatin |
| Mol File: | 58970-76-6.mol |
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| Ubenimex Chemical Properties |
| mp | 245 °C (dec.)(lit.) |
| storage temp. | 2-8°C |
| Merck | 13,9910 |
| CAS DataBase Reference | 58970-76-6(CAS DataBase Reference) |
| Safety Information |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | OH2915000 |
| MSDS Information |
| Provider | Language |
|---|---|
| Ubenimex | English |
| ACROS | English |
| SigmaAldrich | English |
| Ubenimex Usage And Synthesis |
| Chemical Properties | white powder |
| Usage | Ubenimex is a competitive aminopeptidase B inhibitor with an IC50 of 100 mg/ml for K562 cells. Proliferation of all the cell lines except KG1 was inhibited by bestatin. P39/TSU, HL60 and U937 were highly sensitive, with 50% growth inhibitory concentration |
| Usage | Bestatin is "pseudo"-dipeptide isolated from Strepotmyces olivreticuli in 1976. Bestatin is a potent aminopeptidase B inhibitor with no carboxypeptidase activity. Bestatin acts as an immunomodulator by activating macrophages and T lymphocytes. Bestatin also exhibits good antitumour activity and is has been investigated in clinical trials. |
| Usage | Bestatin is "pseudo"-dipeptide isolated from Streptomyces olivreticuli in 1976. Bestatin is a potent aminopeptidase B inhibitor with no carboxypeptidase activity. Bestatin acts as an immunomodulator by activating macrophages and T lymphocytes. Bestatin also exhibits antitumor activity and has been investigated in clinical trials. |
| Biological Activity | Aminopeptidase inhibitor (K i = 0.001-90 mM); inhibits enkephalin metabolism and leukotriene A 4 hydrolase. Inhibits tumor cell proliferation. |
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