HENAN SUNLAKE ENTERPRISE CORPORATION
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supplier - 8th
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Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86-371- 86259723
Tel: 17734809689
Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
Mobile: 17734809689
Tel: +86-371- 86259723
Fax: +86-371- 86259723
Province/state: HENAN
City: ZHENGZHOU
Street: Mingmen International Center, NO.222 Dongming Road,Zhengzhou,Henan,China
MaxCard:
Contact Suppliers
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
About Service
1. Quality control, before shipment, free sample for test.
2. Prompt shipment with professional documents
3. Packing as your request, with photo before shipment
4. Mixed containers with different mixed items in one container
About Company
| Product Name: | Pyrimethamine |
| Synonyms: | 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine;2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine;2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-;2,4-Pyrimidinediamine, 5-(p-chlorophenyl)-6-ethyl-;2,4-Pyrimidinediamine,5-(4-chlorophenyl)-6-ethyl-;4753 R.P.;4753r.p.;5-(4’-chlorophenyl)-2,4-diamino-6-ethylpyrimidine |
| CAS: | 58-14-0 |
| MF: | C12H13ClN4 |
| MW: | 248.71 |
| EINECS: | 200-364-2 |
| Product Categories: | APIs & Intermediate;Pyrimidine;Organics;Amines;Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Inhibitor;Heterocycle-Pyrimidine series;DARAPRIM |
| Mol File: | 58-14-0.mol |
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| Pyrimethamine Chemical Properties |
| mp | 233-234°C |
| storage temp. | 0-6°C |
| Water Solubility | <0.01 g/100 mL at 21 ºC |
| Stability: | Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 58-14-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Pyrimethamine(58-14-0) |
| EPA Substance Registry System | 2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl- (58-14-0) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | UV8140000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| MSDS Information |
| Provider | Language |
|---|---|
| 2,4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine | English |
| SigmaAldrich | English |
| Pyrimethamine Usage And Synthesis |
| Chemical Properties | White Solid |
| Usage | Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial |
| Usage | For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine |
| General Description | Odorless white crystalline powder. Tasteless. An antimalarial drug. |
| Air & Water Reactions | Insoluble in water. |
| Reactivity Profile | Pyrimethamine is sensitive to exposure to light . Neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. |
| Fire Hazard | Flash point data for Pyrimethamine are not available; however, Pyrimethamine is probably combustible. |
| Biological Activity | Potent inhibitor of multi-drug and toxin extrusion (MATE) transporters (K i values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR). |
| Pyrimethamine Preparation Products And Raw materials |
| Raw materials | Ethyl propionate-->4-Chlorobenzyl cyanide |