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CAS NO.56392-17-7
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| Metoprolol tartrate Basic information |
| Product Name: | Metoprolol tartrate |
| Synonyms: | (+-)-1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanolhemi-l-tartr;(+-)-1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanoltartrate(2:;1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-2-propano(+-)-2-propanot;1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propano(+-)-2-propanotartrate;artrate(2:1);beloc;betaloc;h93/26 |
| CAS: | 56392-17-7 |
| MF: | 2C15H25NO3.C4H6O6 |
| MW: | 684.82 |
| EINECS: | 260-148-9 |
| Product Categories: | Cardiovascular;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Adrenoceptor;UROXATRAL;Cardiovascular APIs |
| Mol File: | 56392-17-7.mol |
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| Metoprolol tartrate Chemical Properties |
| storage temp. | Desiccate at RT |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 56392-17-7(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | F,T |
| Risk Statements | 11-23/24/25-39/23/24/25 |
| Safety Statements | 7-16-36/37-45 |
| RTECS | UB7450100 |
| MSDS Information |
| Provider | Language |
|---|---|
| 1-(Isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol (2:1) Dextro-tartrate salt | English |
| Metoprolol tartrate Usage And Synthesis |
| β1 receptor blocker |
Metoprolol tartrate is a selective β1-adrenergic receptor blocker,oral absorption is rapid and complete,it is used for the treatment of hypertension, angina pectoris, myocardial infarction, hypertrophic cardiomyopathy, aortic dissection, cardiac arrhythmia, hyperthyroidism, cardiac neurosis and other diseases. In recent years, it is also used for ther treatment of heart failure, which can reduce mortality. In unstable / non-ST-segment elevation myocardial infarction and acute myocardial infarction control guiding principles developed by American Heart Association , effect of metoprolol tartrateare is clearly recognized. In the past, concerns about β-blocker therapy caused hypotension is too large, and for the consideration that there may be racial differences between Asians in β-blocker use and the West, patients with treatment of β-blockers in China is fewer , the use of β-blockers is in lower dose. Metoprolol tartrate has a weaker membrane stability and it has no intrinsic sympathomimetic activity, and in comparison with similar drugs commonly used in clinical propranolol ,in addition to the advantages of β1-blocker on its pharmacodynamic,it also has its pharmacokinetic kinetics advantages, such as relatively weak first-pass effect compared with propranolol, simple metabolic pathways, most pharmacologically inactive metabolites and the like. |
| Uses | Hypertensive medication. |
| Hazards & Safety Information |
Category: toxic substances Toxicity grading: Middle poisoning Acute toxicity: oral - rat LD50: 5500 mg / kg; Oral - Mouse LD50: 1500 mg / kg Flammability and hazard characteristics: It is combustible; fire decomposition produces toxic nitrogen oxide gases Storage Characteristics: Ventilated, low-temperature ,dry storeroom. Extinguishing agent: Water, carbon dioxide, dry powder, sandy soil. |
| Chemical Properties | Crystalline Powder |
| Usage | A selective aryloxypropanolamine andrenergic antagonist. Used in the treatment of a variety of cardiovascular disorder. Antihypertensive; antianginal; antiarrhythmic (class II) |
| Usage | A β1 selective aryloxypropanolamine andrenergic antagonist. Used in the treatment of a variety of cardiovascular disorder. Antihypertensive; antianginal; antiarrhythmic (class II). |
| Usage | alpha(1)-adrenergic blocker |
| Usage | A b1-Adrenergic blocker |
| Biological Activity | Selective β 1 -adrenoceptor antagonist (K i values are 47, 2960 and 10100 nM for β 1 , β 2 and β 3 adrenoceptors respectively). Inhibits spontaneous endothelin-1 production in vitro and displays antihypertensive and antianginal activity in vivo . |
| Metoprolol tartrate Preparation Products And Raw materials |