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• SALE 501-36-0 99%(HPLC)
• offer 501-36-0 3,4',5-trihydroxy-trans-stilbene;5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol
• own lab offer 501-36-0 3,4',5-trihydroxy-trans-stilbene;5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol

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• ProName: 3,4',5-trihydroxy-trans-stilbene;5-[(1...
• CasNo: 501-36-0
• Molecular Formula: C14H12O3
• Appearance: white crystalline powder
• Application: 501-36-0
• DeliveryTime: Promopt .
• PackAge: 1g;5g;10g;25g;50g;100g;500g;1KG;5KG,25...
• Port: China main ports
• ProductionCapacity: 100 Kilogram/Month
• Purity: 99%
• Storage: Room temperature with sealed well
• Transportation: by air /by sea /by courier
• LimitNum: 1 Kilogram
• Valid Period: 6 month
• Application: Multipurpose intermediate
• Certification: ISO/9001 Certificate

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HenNan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material . 
Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas. 

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Resveratrol Basic information

Overviews Origin Extraction of resveratrol from Polygonum cuspidatum Contents determination methodPharmacological effects The synthetic method of resveratrol Solubility Toxic activity Chemical propertyApplication

Product Name:	Resveratrol
Synonyms:	TRANS-3,4',5-TRIHYDROXYSTILBENE;TRANS-3,4,5-TRIHYDROXYSTILBENE;TRANS-3,5,4'-STILBENETRIOL;TRANS-RESVERATROL;TRANS-1,2-(3,4',5-TRIHYDROXYDIPHENYL)ETHYLENE;RESVERATROL;RESVERATROLE;3,4',5'-TRIHYDROXY-TRANS-STILBENE
CAS:	501-36-0
MF:	C14H12O3
MW:	228.24
EINECS:
Product Categories:	Stilbenes (substituted);Miscellaneous;Antioxidant;Biochemistry;Stilbenes;Natural Plant Extract;Beauty;The group of Polydatin;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Caspases/Apoptosis;Health supplements;Plant extracts;Inhibitor;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product
Mol File:	501-36-0.mol

Resveratrol Usage And Synthesis

Overviews	Resveratrol is a natural antioxidant. It can reduce blood viscosity, inhibit platelet aggregation and vasodilation, keep the blood flowing and prevent the occurrence and development of cancer. It has the function to prevent and treat atherosclerosis, coronary heart disease, ischemic heart disease and high blood cholesterol. It has an effect on suppressing tumor. Resveratrol also has estrogen-like effects that can be used to treat breast cancer and other diseases. It can retard aging and prevent cancer. Red grape skins, red wine and grape juice have high concentrations of resveratrol. Studies have shown that the integrity of the chromosomes will be destroyed as the human aging. But resveratrol can activate proteins that can repair chromosome, thus delaying aging.
Origin	Resveratrol is anthraquinone terpenoids. It mainly comes from rhizome extract of polygonum cuspidatum. Polygonum cuspidatum: Shrubby perennial herb, up to 1 meter or more. Rhizome lying underground, wood brown, section significantly. Stems erect and cylindrical, surface glabrous, scattered with most red spots, hollow. Leaves alternate, broadly ovate to nearly circular, long 7-12cm, width 5-9cm, apex mucronate, base rounded or cuneate; petiole 1-1.5cm sheath care quality, brown, early fall. Flowering is from July to September, and fruiting from September to October. Spring and autumn can be excavated, cut and dried. Polygonum cuspidatum is born in the valley, creek or shore, located in central and southern country, and produced in Jiangsu, Zhejiang, Jiangxi, Fujian, Shandong, Henan, Shaanxi, Sichuan and other places.
Extraction of resveratrol from Polygonum cuspidatum	Polygonum cuspidatum is the rhizome of polygonaceae polygonum cuspidatum. The main production areas are Jiangsu, Zhejiang, Anhui, Guangdong, Guangxi, Yunnan, Sichuan, Guizhou and other places. In spring and autumn, the roots will be dug and removed the fibrous roots, then washed and dried. Polygonum cuspidatum rhizome contains free anthraquinone and anthraquinone glycosides, whch mainly are emodin ether, rhubarb phenol, anthracene glycosides A and B, etc. It also contains resveratrol glycosides, polydatin, protocatechuic acid, dextrose catechin, tree anthrone-8-glucosidecassia, β-sitosterol glucoside and glucose, rhamnose, ginger candy, amino acids, tannin and copper, iron, manganese, zinc, potassium and potassium salts, etc. Figure 1 is Polygonum cuspidatum plant Resveratrol (Res) is a non-flavonoid polyphenol compound. It is considered as a phytoalexin, which is generated when the plant is attacked by pathogenic, or in the poor environment. It is mainly found in grapes, giant knotweed, peanuts, mulberry, pine, Gnetum, Korea Huaifrom 12 families and 31 genera of 72 species of plants. Extraction of the natural plant: polygonum cuspidatum is used as raw material, extracted, extracted resveratrol crude, and then purified. Crude extraction technologies include organic solvent extraction method, the new method of alkaline extraction and enzymatic extraction method. New methods like microwave-assisted extraction, CO2 supercritical extraction and ultrasonic extraction are also applied. The main purpose of purification is to extract cis-resveratrol and trans-resveratrol and polydatin from raw resveratrol to obtain trans-resveratrol. Common methods of purification are chromatography, silica gel column chromatography, thin-layer chromatography, high performance liquid chromatography and the like. Resveratrol had significant antioxidant activity on animal fats. Sample of 240mg/kg shows the strongest antioxidant activity during the three samples whose concentration of resveratrol is respectively 120 mg/kg, 240mg/kg, 360mg/kg. In antioxidant tests on lard, the antioxidant effect of resveratrol is stronger than polyphenols with same concentration.
Contents determination method	C18 column, mobile phase consisted of acetonitrile and water (volume ratio 30: 70), and UV detection at 30 6nm are used to detect. The results show that if the concentration of resveratrol is in 10~250 μg/mL, concentration and peak area show a good linear relationship (r = 0.9999); the recovery is 925% to 1026%; the lowest detectable concentration is 0.6mg/g. The flow rate can be adjusted to detect the enzymatic conversion of polydatin and resveratrol at the same time.
Pharmacological effects	Resveratrol is not only the chemopreventive agents of neoplastic diseases, but also the chemopreventive agents to reduce platelet aggregation and prevent and treat atherosclerosis, cardiovascular and cerebrovascular disease. In the 1990s, studies of science and technology workers on resveratrol have advanced, and reveal its pharmacological effects. It can inhibit normal platelet aggregation, prevent myocardial cram, cerebral embolism. It has a protective effect on cardiac hypoxia, restore decline of cardiac output which is caused by burn or hemorrhagic shock, and can expand arteries and improve microcirculation. In 1998, United States Al.Mindell listed resveratrol as one of “the 100 most popular and effective anti-aging substance” when he compiled the anti-aging Scripture. Professor Mao Wenyue, researcher of Chinese academy of agricultural sciences and the national peanut research institute and national famous medicine expert, said that research and development of the resveratrol in peanut (Protein and fat content in peanut is higher than meat, eggs. The ancients called it "ChangshengGuo"), will be one of the most important nutrition issues of the 21st century. So far, NASA has made peanuts as space food. Eating peanut products frequently can alleviate cardiovascular disease, lower cholesterol, and slow down aging. Peanut oil, peanut butter and other foods rich in resveratrol will be the new fashion of nutrition and health in the 21st century. Resveratrol is the chemopreventive agents of neoplastic diseases, but also the chemopreventive agents to reduce platelet aggregation and prevent and treat atherosclerosis, cardiovascular and cerebrovascular disease. Resveratrol shows some inhibitory effect on staphylococcus aureus, the card he bacteria, escherichia coli, pseudomonas aeruginosa, and has a stronger inhibitory effect on the orphan virus, herpes simplex virus, and enteroviruses, coxsackie a, b groups. In the 1990s, studies of science and technology workers on resveratrol have advanced, and reveal its pharmacological effects. It can inhibit normal platelet aggregation and prevent myocardial cram, cerebral embolism. It has a protective effect on cardiac hypoxia, restore decline of cardiac output which is caused by burn or hemorrhagic shock, and can expand arteries and improve microcirculation. Resveratrol is an anti-free radicals, anti-oxidants. It is associated with the following functions: 1.Slow down the aging. 2.Prevent the oxidation of low density lipoprotein. Have the effect on preventing potential cardiovascular disease (atherosclerosis and coronary heart disease, ischemic heart disease, hyperlipidemia, etc.). 3.Affect metabolism of lipid and arachidonic acid. 4.Anti-thrombotic and anti-platelet aggregation. 5.Anti-inflammatory and anti-allergic effects.
The synthetic method of resveratrol	Resveratrol is an inhibitor of many oxidative metabolism enzymes of aromatic carcinogens. It is named as the natural chemopreventive agents of cardiovascular and cerebrovascular diseases and cancer. Many studies have shown that resveratrol also has many functions, such as anti-mutagenic activity, protecting cell toxicity induced by the oxidation of lipoprotein, inhibiting tumor cell reproduction, and so on. Human separated resveratrol from the root of veratrum grandiflorum for the first time in 1940. Researchers currently has found resveratrol from at least 21 families and 31 genera of 72 species of plants, such as grape vine genus, vitis snake, legumes arachis, cassia, sophora, polygonum, and so on. Because of the low concentration of resveratrol in the plant and the high extraction cost, using chemical, biological, genetic engineering and other methods to obtain resveratrol has become an indispensable means for its development process. The roadmap to synthesis resveratrol is as follows: 3,5-dihydroxybenzoic acid (3) forms 3,5-dihydroxybenzoic acid methyl ester (4) by esterification reaction. Choose methyl ether as phenolic hydroxyl- protecting groups. (4) reacts with dimethyl sulfate to get 3,5-di-methoxybenzoate (5). (5) generates the corresponding benzene methanol (6) after reduction, and forms 3, 5 - dimethoxy benzyl bromide (7) through further bromination. Then diethyl (3,5-dimethoxy benzyl) phosphonate (8) can be get by roman abramovich's reaction. (8) reacts with p-anisaldehyde to form the key intermediate 3,4,5- trimethoxy-trans-stilbene (9) via Wittig-Honer reaction. Finally, methyl can be removed by freshly prepared aluminum triiodide. Then the aimed product resveratrol can be separated by thin layer chromatography.
Solubility	Resveratrol is a kinds of natural antioxidants that presents in grapes, red wine, mulberries, peanuts and polygonum cuspidatum. It is polyphenols. It is soluble in organic solvents but insoluble in water. Its dissolved order in organic solvents is: acetone > ethanol> methanol> ethyl acetate> ether> chloroform.
Toxic activity	Hormonal and genotoxic activity of resveratrol: experiments show that the process of resveratrol inducing cytotoxicity, micronucleus and metaphase chromosome inversion can be observed in the course of L5178Y mouse lymphoma. The induction of micronuclei can be observed in the cells of chinese hamster V79. Kinetochore signals and cell cycle analysis of micronuclei show that resveratrol does not directly disrupt polymerization of tubulin which is released by mitotic cells. Studies show that resveratrol has no direct effect on the microtubules collection. Mechanisms of protecting mitochondrial function: Some scholars studied isolated mitochondria of the rat brain tissue by hypoxia-reoxygenation rat model. They found that resveratrol can completely block the release of cytochrome C through the concentration-dependent way. When the concentration is 1nmol, it can significantly reduce the generation of superoxide anion. The damage of mitochondrial protective film caused by hypoxia-reoxygenation can get about 70% of the protection at 0.1 micromolar. In the presence of NADH and cytochrome C, a low median effective concentration (18.34pm) of resveratrol can block mitochondrial oxygen consumption. Three mechanisms for resveratrol to protect mitochondria: antioxidant properties, complex Ⅲ role and membrane stabilization. Peripheral resistance to pain: 1% formalin is used to verify the effect. The results show that resveratrol opens a large and a small K+ channels activated by conductance Ca2+ instead of ATP-sensitive K+ channels, which generates the anti-pain effect in the experiment. Those prove anti-pain effect of resveratrol related with K+ channel. Voltage-dependent K+ channels may also be involved.
Chemical property	Tasteless, white powder, completely dissolved in ethanol.
Application	1.It can prevent the oxidation of low density lipoprotein, and has the potential effect on preventing cardiovascular disease, cancer, antivirus and immune regulation. Its main role is antioxidant properties. 2.Cardiovascular drugs. It can reduce hematic fat and prevent heart disease. It also has the effect on AIDS. 3.Antioxidants and the activity in anti-inflammatory, antithrombotic, anti-cancer, anti-cancer, anti hyperlipidemia and antibacterial. 4.Anti-aging, regulating blood lipid, cardiovascular protection, anti-hepatitis.
Chemical Properties	Off-White to Tan Powder
Usage	antifungal, antibacterial
Usage	Resveratrol is a phytoalexin produced naturally by several plants with anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects
Usage	Minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1, and it also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression.
Usage	raw material for Tamiflu; Oseltamivir
Usage	resveratrol can reduce blood fat and the incidence of coronary heart disease. Resveratrol have special protection for cardiovascular system. Adjust the ratio of low-density lipoprotein (LDL); and reducing platelet aggregation effects; anti-aging, is expected to become a natural drug prevent cancer for human.
Biological Activity	A phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects. Inhibits cytochrome P450 1A1 (IC 50 = 23 μ M) and displays mixed agonist/antagonist actions at ER α and ER β estrogen receptors. Converted into the anticancer agent piceatannol (4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,2-benzenediol ) by cytochrome P450 1B1