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CAS NO.50-65-7
1(10-100)Metric Ton1(10-100)Metric Ton
| Niclosamide Basic information |
| Product Name: | Niclosamide |
| Synonyms: | 2’,5-dichlor-4’-nitro-salizylsaeureanilid;2’,5-dichlor-4’-nitro-salizylsaeureanilid[german];2’,5-dichloro-4’-nitro-salicylanilid;5-chloro-n-(2-chloro-4-nitrophenyl)-2-hydroxy-benzamid;5-chlorosalicyloyl-(o-chloro-p-nitranilide);b2353;bay2353;bayer2353 |
| CAS: | 50-65-7 |
| MF: | C13H8Cl2N2O4 |
| MW: | 327.12 |
| EINECS: | 200-056-8 |
| Product Categories: | Veterinaries;API's;Pharmaceutical intermediate;PERMAX;Other APIs;intermediates |
| Mol File: | 50-65-7.mol |
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| Niclosamide Chemical Properties |
| storage temp. | 0-6°C |
| CAS DataBase Reference | 50-65-7(CAS DataBase Reference) |
| EPA Substance Registry System | Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)- 2-hydroxy-(50-65-7) |
| Safety Information |
| RIDADR | UN 3077 9/PG 3 |
| WGK Germany | 2 |
| RTECS | VN8400000 |
| Hazardous Substances Data | 50-65-7(Hazardous Substances Data) |
| MSDS Information |
| Provider | Language |
|---|---|
| Niclosamide | English |
| SigmaAldrich | English |
| Niclosamide Usage And Synthesis |
| Anti-parasitic disease drug |
Niclosamide belongs to the taeniafuge drugs of the anti-parasitic disease drugs , it is less toxic, it has a high efficacy on a variety of tapeworm, tapeworm mechanism is hampering tapeworm Krebs cycle, so that lactic acid is accumulated which can cause the death of the parasites, it is drug of choice in livestock and poultry, pet tapeworm prevention . Oral absorption from the gastrointestinal tract is very little, so it can maintain a high concentration in the intestine, it has a strong insecticidal action against the pork tapeworm, and beef tapeworm short Hymenolepis . Low concentrations of the drug can promote parasite uptake, while high concentrations of the drug can inhibit mitochondrial oxidative phosphorylation of the parasite, and hinder the absorption of glucose uptake,and result in tapeworm head and proximal segments death, and elimination with the feces from the intestinal wall . Mainly it is used for tapeworm infection, but it is also used as molluscidal drugs which can kill snails and snail eggs, cercariae and miracidia. It has high rate of snail eradication , slow effect, long residual effect, it is used for the prevention of schistosomiasis, the temperature above 20 ℃ is better. In addition ,the product is friendly to human, animal and plant,it is very toxic to fish, so use in the fish ponds is forbidden . 1960 Germany reported a synthetic chemical repellent - Niclosamide whose code is Bayer 73 the drug is pale yellow powder, odorless, tasteless. Insoluble in water, slightly soluble in alcohol, ether and chloroform,it can be dissolved in hot ethanol, cyclohexanone and an aqueous solution of sodium hydroxide, the compound is stable.Niclosamide have a better effect on beef tapeworm, pork tapeworm, H. nana and Diphyllobothrium tapeworm, . Few drug absorption occurs in the gastrointestinal tract, when the drug is exposed with parasites, parasites die soon. Therefore, when the medication, the tablets should be chewed, so drugs can make full contact with tapeworm parasites, and a lot of water immediately should be avoided, in order to maintain a high concentration of upper small intestine where lies the parasitic tapeworm . The drug can kill adults tapeworm rather than eggs tapeworm , in order to prevent vomiting, which make the eggs reflux into stomach , and cause the risk of cysticercosis occurring, anti-emetics should be added before the medication . 2 hours after administration, it should be served magnesium sulfate for catharsis, to get rid of the parasite and the cleaved head section and debris. The drug has low toxicity, rat oral LD50 of 5g / kg. This product can also be made with amino ethanol to serve as soluble snail drugs under the trade name niclosamide (bayluscide),in the country, Niclosamide and alkali waste pulp can be made for soluble pastes, called schistosomiasis - 67. These can be used to kill the snail which is the intermediate host of Schistosoma japonicum. Regardless of spraying or soaking ,the amount of snail, is 1g / m2. Pulp paste for live use (ie schistosomiasis-67), accounts for 50% of Niclosamide . Oral adverse reactions are mild, except for gastrointestinal reactions, occasional dizziness, chest tightness, fever and other discomfort occur. There is no liver, kidney, blood system injury. The above information is edited by the chemicalbook of Tian Ye. |
| Chemical Properties | Yellow-white crystalline powder, odorless, tasteless. Melting point 225-230 ℃. Insoluble in water, soluble in hot ethanol, chloroform, cyclohexanone, diethyl ether and sodium hydroxide solution. |
| Application |
It is used to control snails, etc. Molluscidal medicine, molluscicides,which are applied to kill the water snails, freshwater oncomelania,it has effect on snails bodies and snail eggs . Alsoit can be used as taeniafuge drugs for repelling beef tapeworm and pork tapeworm. |
| Production Method | The same amount of 2-chloro-4-nitroaniline and 5-chloro-salicylate are dissolved in xylene (or chlorobenzene), it is heated to boiling, then it is slowly added phosphorus trichloride (or phosphorus oxychloride), after that the reflux is continued for 3h. After cooling, the crystals are filtered off, the product is produced. |
| Category | Pesticide |
| Toxicity grading | Middle toxic |
| Acute toxicity | Oral - rat LD50: 2500 mg / kg; Oral - Mouse LD50: 1000 mg / kg |
| Flammability and hazard characteristics | It produces toxic chloride and nitrogen oxide gases from combustion. |
| Storage Characteristics | Ventilated, low-temperature ,dry storeroom.It should be stored and transported separately From food raw materials |
| Extinguishing agent | Dry powder , foam, sand |
| Usage | dopamine receptor agonist |
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Niclosamide Preparation Products And Raw materials |
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