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Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
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Tel: +86-371- 86259723
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| Oxytocin Basic information |
| Product Name: | Oxytocin |
| Synonyms: | +CYS-TYR-ILE-GLN-ASN-+CYS-+PRO-LEU-GLY-NH2;CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2;CYIQNCPLG-NH2;CYIQNCPLG-NH2 (DISULFIDE BRIDGE: 1-6);H-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2;H-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, CYS1,6, CYCLIC;H-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2 (DISULFIDE BRIDGE: 1-6);A-HYPOPHAMINE |
| CAS: | 50-56-6 |
| MF: | C43H66N12O12S2 |
| MW: | 1007.19 |
| EINECS: | 200-048-4 |
| Product Categories: | Amino Acid Derivatives;Organics;Amino Acids 13C, 2H, 15N;Peptide;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Vasopressin and Oxytocin receptor;Peptide Receptors;hormones;peptides for birth-giving use;Veterinary drugs |
| Mol File: | 50-56-6.mol |
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| Oxytocin Chemical Properties |
| mp | 192-194°C |
| storage temp. | 2-8°C |
| form | lyophilized powder |
| Merck | 13,7049 |
| CAS DataBase Reference | 50-56-6(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | RS7534000 |
| F | 3-8-10-23 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| Hazardous Substances Data | 50-56-6(Hazardous Substances Data) |
| MSDS Information |
| Oxytocin Usage And Synthesis |
| Uterine contraction drugs |
Oxytocin is also called Pitocin, is a kind of uterine contraction medicine, can be extracted from animal posterior pituitary or chemical synthesis, chemical synthesis including on vasopressin, no booster effect, selective excitate uterine smooth muscle, strengthen its contracting, uterus is most sensitive to oxytocin (estrogen secretion increase) when parturient Common used with ergot preparations, treatment for postpartum hemorrhage; Inevitable abortion; Mainly used in late pregnancy induced labor and intrapartum uterine contractions fatigue caused by prolonged labor; Used for oxytocin sensitive test; Used for oxytocin irritability test; Assist in postpartum milk discharge; Haemoptysis. Postoperative gastrointestinal peristalsis slowly. The above information is edited by the Chemicalbook of Duan Yalan. |
| Chemical Properties | White to brown powder, has the water absorbability, soluble in water. |
| Application |
This product can absorb from the oral mucosa, and selectively acts on the smooth muscle of the uterus, make uterine contractions. Apply to hastening parturition and slow painful. Effect is the same as the static drops of oxytocin. For contracted pelvis, has a history of uterine surgery (including cesarean section), pain excessive hyperfunction, birth canal obstruction, severe placental abruption, maternal pregnancy poisoning are prohibited. Uterine contractions. Used for induced labor, oxytocin, postpartum and abortion after uterine bleeding caused by contractions weak and so on. Intranasal can make milk. Adverse reactions and taboos: birth, apparent cephalopelvic |
| Production Method |
Method 1, extraction method (using in China, the purity is low, but the cost is low) Oxytocin liquid extract. Take 100 g of leaf powder, 30 g of quartz powder in the ball mill, add distilled water, extracting four times with the same method. Join 1.4 L of distilled water two times, 1.3 L twice. Each extract 45 min, centrifugal, collect the liquid and residue is extracted. Merge extract of the four times for a quick fluid of oxytocin. After leaf powder/water, ball mill →oxytocin extract. Chromatography separation. Add 1500 g of good handled synthetic zeolite to 20 L of 0.25% acetic acid solution, stir and pour exchange column with ethyl acid decreased by more than to the surface of zeolite 2-3 cm, add to extract liquor Oxytocin extract [HAc, synthetic zeolite]→turbid liquid [HAc, heating]→ separation liquid. Adsorption, elution to the next day, filtrate the refrigerated liquid, add 10% bentonite slurry (per 100 ml and 3 ml) to the filtrate under stirring, stir 1 h, adsorption, centrifugation. Examinate Supernatant fluid with sulfosalicylic acid fluid, not settling for adsorption completely. If not completely, adsorption again, merging two bentonite slurry precipitation. Bentonite elution four times with 1% acetic acid (1.6 L and 1.4 L and 1.2 L and 0.8 L), every time add the eluent with tertiary butyl alcohol when heated to 80 oC, then heat up to 95 oC, rapid cooling to 25 oC, filtration or centrifuge, merge the filtrate, four testing titer and vasopressin. Refrigerated liquid [filter] →filtrate liquor [bentonite slurry]→ adsorbate [ 1% HAc]→ eluent Oxytocin injection preparation Dilute qualified oxytocin liquid to 5u/ml or 10 u/ml, through 4 or 5 sintered filter funnel, potting, circulating steam sterilization for 30 min at 100 oC to obtain product. Oxytocin liquid (measurement qualified) [filter filling and sealing]→oxytocin injection. Note: synthetic zeolite treatment New zeolite after 60-80 mesh sieve, added 2 L distilled water per 500 g, use sodium hydroxide to adjust to pH9, keep half an hour, leaning to the supernatant, add 2 L water, adjust pH to 9 again, pour to clear liquid again, add water, stir and add dilute sulphuric acid to pH 5.8-6 and stir for half an hour, pour to clear liquid, wash 7-8 times repeatedly and each time with water. Add1 L water and dilute sulphuric acid, mixed for half an hour, pour to clear liquid, washed with water to pH7, drain and dry. Set aside. Regeneration of synthetic zeolite Wash synthetic zeolite twice times with distilled water, then add 1.5 L of water (calculated on zeolite 500 g) and 150 g of sodium chloride, stir for 2 h, wash to remove vasopressin, again wash with distilled water to without chloride ion. Add right amount water, with sodium hydroxide to adjust pH to 9, mix half an hour, pour to clear liquid, wash with distilled water, with sulfuric acid to adjust pH to 5.5-6, and then washed with water to nearly neutral, drain, dried at 105 oC. Set aside. Before using, add right amount of water and glacial acetic acid, stirring soak. 10% of Bentonite slurry preparation mixed bentonite with water according to the volume proportion of 1:10, grinding about 1 h, and adjust the grinding with acetic acid to pH 3.5, placed in the refrigerator and set aside. Method 2, chemical synthesis method Start with benzyl oxygen carbonyl leucine p-nitrophenyl acetate synthesis peptide 7 amide (3-9), synthesis of benzyl oxygen carbonyl acyl - S - benzyl in, cheese ammonia acyl azide (1-2 paragraphs), the third step synthetic oxytocin. |
| Chemical Properties | White Solid |
| Usage | Oxytocin is the principal uterus-contracting and lactation-stimulating hormone of the posterior pituitary gland. |
| Oxytocin Preparation Products And Raw materials |
| Raw materials | Silicon dioxide-->Bentonite-->Aluminosilicate-->5-Sulfosalicylic acid dihydrate-->PERCOLL-->Vasopressin |
| Preparation Products | H-HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-NH2 |