Keywords

• CAS:491-70-3 C15H10O6 Luteolin
• CAS:491-70-3 C15H10O6 factory price high purity 99%
• CAS:491-70-3 technical grade or OLED grade

Quick Details

• ProName: CAS:491-70-3 C15H10O6 Luteolin
• CasNo: 491-70-3
• Molecular Formula: C15H10O6
• Appearance: white poweder
• Application: CAS:491-70-3 technical grade or OLED g...
• DeliveryTime: 5 working days after cash deposit
• PackAge: Plastic vacuum packaging bag or bucket
• Port: depend on clients require
• ProductionCapacity: 1 Metric Ton/Day
• Purity: 99%
• Storage: under the cool and dry area
• Transportation: by express or by sea
• LimitNum: 500 Gram
• Grade: Industrial Grade,Food Grade,Pharma Gra...

Superiority

Luteolin Basic information

Natural Flavonoids Solubility Extraction Method Pharmacological activity Pharmacological effects Pharmacokinetics Indications Adverse reactions

Product Name:	Luteolin
Synonyms:	2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4h-1-benzopyran-4-on;3’,4’,5,7-tetrahydroxy-flavon;c.i.75590;c.i.naturalyellow2;cyanidenon1470;digitoflavone;luteoline;weldlake
CAS:	491-70-3
MF:	C15H10O6
MW:	286.24
EINECS:	207-741-0
Product Categories:	Tetra-substituted Flavones;Natural Plant Extract;Inhibitors;Tyrosine Kinase Inhibitors;Cytokine signaling;Plant extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product
Mol File:	491-70-3.mol

Luteolin Usage And Synthesis

Natural Flavonoids	Luteolin is a very typical kind of natural flavonoid and belongs to weak acidic tetrahydroxy flavonoids. It is widely distributed in the plant kingdom and is mainly presented in honeysuckle, chrysanthemum, Nepeta, Herba Ajuga and some other drugs as well as many kinds of vegetables such as thyme, Brussels sprouts, cabbage, cauliflower, beets, broccoli and carrots. Moreover, it is also distributed in the form of glycosides in celery, green pepper, and basil leaves as well as the fruit shell of the legume plant Arachis hypogaea, Ajuga decumbus, Lonicera japonica Thunb, Gentianaceae plant Gentianopsis paludosa, and Valerianaceae plant Valeriana amurensis Smir. The pure product of Luteolin appears as yellow crystalline powder. Figure 1 the pale yellow powder of luteolin and its sources of plant.
Solubility	Luteolin is a golden needles product containing a crystal water molecule that is precipitated from ethanol. It is soluble in alcohol and diethyl ether; slightly soluble in hot water, and insoluble in cold water. Its aqueous solution exhibits pleasing yellow and can be dissolved in 10% aqueous solution of sodium hydroxide and appears as dark yellow color. It is stable under normal conditions.
Extraction Method	According to the report of the literature, method for extracting the active ingredient luteolin from the peanut shell includes solvent method, ultrasonic method, microwave method and supercritical CO2 method, wherein the solvent extraction method is the most widely used with the major extraction solvents used being methanol, acetone and ethyl acetate.  The above information is edited by the Chemicalbook of Dai Xiongfeng.
Pharmacological activity	1. Luteolin has various kinds of pharmacological activities. Plants rich in luteolin content are often used as a traditional Chinese medicine for treatment of disease. With the deepening of the study on luteolin, researchers have found that it have anti-cancer activities including inhibiting the proliferation of tumor cell, inducing the apoptosis of tumor cells as well as sensitizing anti-cancer drugs. Moreover, it also has anti-inflammatory, anti-oxidant as well as protein effect on the nervous system.  2. Luteolin is a kind of PDE4 inhibitors, phosphodiesterase inhibitors (2) and interleukin-6 inhibitor (3). It can significantly reverse the induction effect of anesthesia of mice xylazine/ ketamine induction of anesthesia. 4 Preclinical studies have shown that the pharmacological effects of luteolin might include anti-oxidant, anti-inflammatory, antibacterial and anti-cancer. Preliminary studies have found that luteolin can inhibit the apoptosis of the angiogenesis induced cell, affect the tumor growth in animal models, reduce the tumor growth and also improve the cytotoxicity of certain anti-cancer drugs on the tumor cell, indicating that luteolin could be potential cancer chemo-preventive drugs and chemotherapy drugs.  3. The mechanism of biological activity of luteolin may be regulating the level of ROS, inhibition of topoisomerase I and topoisomerase II, reducing the transcription factor NF-κB and AP-1, and stabilizing p53 and inhibition of phosphatidylinositol 3 - kinase, signal transduction and activator of transcription 3 (STAT3), insulin-like growth factor 1 receptor (IGF1R) and human epidermal growth factor receptor II activity.
Pharmacological effects	1, anti-tumor: the inhibitory effect of luteolin on tumor cell proliferation is mainly through inhibiting certain intracellular kinase activity and causing cell cycle arrest.  2. Antioxidant: the antioxidant effect of luteolin itself mainly exhibits as a reducing agent involved in the oxidation reaction as well as enhancing the activity of the biological antioxidant system. 3, Anti-inflammatory: the anti-inflammatory activity of luteolin is mainly manifested that it can reduce the activity of inflammatory cytokine transcription factor and production of the pro-inflammatory cytokines and inflammatory mediators. 4, the neuro-protective effect: luteolin has protective effect on the learning and memory ability of the nervous system. 5, anti-fibrosis: luteolin can reduce the extent of liver fibrosis, reduce the hydroxyproline (HYP) in the liver tissue, the content of malondialdehyde (MDA) and the mRNA expression of type I pro-collagen mRNA. In vitro, it can inhibit the proliferation of hepatic star like cells (HSC) and collagen synthesis. It can also alleviate the bleomycin-induced pulmonary fibrosis and histopathological changes, reduce the lung weight index, significantly suppress the increase of MDA, HYP and inhibit the expression of transforming growth factor-β1 (TGF-β1) mRNA in the lung tissue. In vitro, it can inhibit the proliferation of human embryo lung fibroblasts, induce the apoptosis. 6, anti-fertility and hormonal effects: luteolin has a significant dose-dependent anti-implantation activity. After oral administration, it can significantly increase the weight, diameter of uterine, the thickness of endometrium and the height of epithelial cells. Single administration has estrogenic effect while its combination with ethinyloestradiol exhibits anti-estrogenic effect. 7, other functions: luteolin can inhibit various kinds of bacteria and viruses, such as Staphylococcus aureus, Escherichia coli, herpes simplex virus, polio virus, Coxsackie B3 virus. It can inhibit the activity of integrase of AIDS virus HIV-1 and therefore has potential anti-HIV effect. Luteolin is able to bind to the s2 protein of the severe acute respiratory syndrome (SARS) corona virus, thus inhibiting viral for entry into host cells. Luteolin also has inhibitory effect on the Leishmania donovani. Through inhibiting the action of the topoisomerase I and topoisomerase II of Leishmania donovani and inhibit their growth. Additionally, luteolin also has immunomodulatory effects and so on.
Pharmacokinetics	The pharmacokinetic experiment of rat has shown that after the oral administration of luteolin by rats, the in vivo plasma concentration is significantly higher than that after acid hydrolysis which demonstrating it is mostly presented in the glucuronic acid-bound form. The biliary study have found that the level of luteolin in the biliary sample is undetectable using HPLC method at each time after the administration if without the hydrolysis treatment, demonstrating that luteolin is mainly presented in the bound form in the bile.
Indications	This product has antitussive, expectorant effect. The antitussive effect is through suppressing the cough center; the expectorant effect of this product is related to its ability of promoting the secretion of the respiratory tract gland and dissolving the acidic mucopolysaccharides in the sputum. It also has anti-inflammatory, anti-allergic and immune enhancement effect. It also has inhibitory effect on Staphylococcus aureus, Streptococcus pneumoniae and Pseudomonas aeruginosa. It can also be used for the treatment of chronic bronchitis and other respiratory diseases sputum.
Adverse reactions	Some patients may get dry mouth, upset stomach, dizziness, nausea and other side effects. After prolonged administration, the symptom may gradually disappear.
Chemical Properties	Yellow Needles
Usage	Hydroxylated flavone derivative with strong anti-oxidant and radical scavenging properties. Suggested to play a role in cancer prevention
Usage	Expectorant
Biological Activity	Anti-inflammatory, antioxidant and free radical scavenger. Inhibits LPS-induced TNF- α , IL-6 and inducible nitric oxide production and blocks NF- κ B and AP-1 activation. Antiproliferative; inhibits proliferation of Lewis lung carcinoma cells in vivo .

Details

1. What kind of package

25kg plastic woven bags or fiber drums.

2. How many goods can be loaded in one 20ft container

20 tons with pallets, 25 tons without pallets

3. What certificate can you supply

COA, MSDS, SGS, ISO

4. Can you supply sample

Less than 500g sample can be supplied.

5. What is the lead-time

Within 15 days after receving payment

6.What is the payment terms

L/C, TT or .

7. What is your terms of delivery

FOB, CNF, CIF and so on.

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