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CAS NO.491-67-8
| Baicalein Basic information |
| Product Name: | Baicalein |
| Synonyms: | 5,6,7-TRIHYDROXY-2-PHENYL-(4H)-1-BENZOPYRAN-4-ONE;5,6,7-TRIHYDROXYFLAVONE;4H-1-BENZOPYRAN-4-ONE,5,6,7-TRIHYDROXY-2-PHENYL-;BAICALEIN, 98+% BY HPLC;BAICALEIN4H-1-BENZOPYRAN-4-ONE,5,6,7-TRIHYDROXY-2-PHENYL-,;Baicalein std.;5,6,7-Trihydroxyflavone,97%;Baicaleine |
| CAS: | 491-67-8 |
| MF: | C15H10O5 |
| MW: | 270.24 |
| EINECS: | |
| Product Categories: | Tri-substituted Flavones;The group of Scutellaria;Inhibitors;Aromatics;Heterocycles;API;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product |
| Mol File: | 491-67-8.mol |
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| Baicalein Chemical Properties |
| mp | 256-271 °C(lit.) |
| storage temp. | 2-8°C |
| Merck | 14,942 |
| BRN | 272683 |
| CAS DataBase Reference | 491-67-8(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-20/21/22 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ALFA | English |
| Baicalein Usage And Synthesis |
| Chemical Properties | Yellow Crystalline Solid |
| Usage | antiviral (HIV) |
| Usage | An inhibitor of 12-lipoxygenase, leukotriene biosynthesis and release of lysosomal enzymes. It also inhibits cellular Ca2+ uptake and mobilization and adjuvant-induced arthritis. Baicalein is the fl avonoid component of Nepalese and Sino-Japanese crude drugs. |
| Usage | inhibitor of lipoxidase and leukotriene biosynthesis |
| Biological Activity | Inhibitor of 5- and platelet 12-lipoxygenases (IC 50 values are 9.5 and 0.12 mM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1 and G2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Anti-inflammatory in vivo . |
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