HENAN SUNLAKE ENTERPRISE CORPORATION
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Tel: 17734809689
Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
Mobile: 17734809689
Tel: +86-371- 86259723
Fax: +86-371- 86259723
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City: ZHENGZHOU
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CAS NO.4759-48-2
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
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About Company
| Product Name: | Isotretinoin |
| Synonyms: | 13-cis-ra;13-cis-retinoicaci;13-ra;accutane;Isoretinoin;isotrex;neovitaminaacid;ro-4-3780 |
| CAS: | 4759-48-2 |
| MF: | C20H28O2 |
| MW: | 300.44 |
| EINECS: | 225-296-0 |
| Product Categories: | Antibiotics;Organic acids;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Retinoids;API;BUSPAR;Other APIs;intermediates |
| Mol File: | 4759-48-2.mol |
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| Isotretinoin Chemical Properties |
| mp | 172-175 °C(lit.) |
| storage temp. | −20°C |
| Water Solubility | insoluble |
| Stability: | Stable, but probably air and light sensitive. Combustible. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 4759-48-2(CAS DataBase Reference) |
| EPA Substance Registry System | Retinoic acid, 13-cis-(4759-48-2) |
| Safety Information |
| Hazard Codes | T |
| Risk Statements | 61-36/37/38-20/21/22 |
| Safety Statements | 53-26-36/37/39-45-37/39 |
| WGK Germany | 3 |
| RTECS | VH6440000 |
| Hazardous Substances Data | 4759-48-2(Hazardous Substances Data) |
| Chemical Properties | Yellow-Orange Crystalline Powder |
| Usage | Used as a treatment for severe acne. Presently being studied in conjuction with the treatment of photoaged skin. |
| Usage | 5HT1a receptor agonist, anxiolytic |
| General Description | Yellow-orange to orange crystalline powder; orange-brown chunky solid. |
| Air & Water Reactions | Insoluble in water. |
| Reactivity Profile | An organic acid and unsaturated aliphatic hydrocarbon. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions. |
| Fire Hazard | Flash point data for Isotretinoin are not available; however, Isotretinoin is probably combustible. |
| Isotretinoin Preparation Products And Raw materials |
| Raw materials | Triphenylphosphine-->Ionone-->Ethylmagnesium chloride-->Palladium nitrate |