HENAN SUNLAKE ENTERPRISE CORPORATION
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Tel: +86-371- 86259723
Tel: 17734809689
Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
Mobile: 17734809689
Tel: +86-371- 86259723
Fax: +86-371- 86259723
Province/state: HENAN
City: ZHENGZHOU
Street: Mingmen International Center, NO.222 Dongming Road,Zhengzhou,Henan,China
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CAS NO.443-48-1
HENAN SUNLAKE ENTERPRISE CORPORATION
Our company advantages:
1、The highest quality with the competitive price.
2、Professional human services.
3、The fastest and safest delivery service.
4、The faster and safest delivery service.
5、The high purity products.
6、We have a sufficient supply of stock.
7、A variety of payments, such as L/C, TT, , MoneyGram or other payments.
Henan Sunlake Enterprise Corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion. The com[any was established in june. 1998, until now having more than 18 years experience in manufacturing & exporting chemical raw material .
Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others. These products have been being well exported to europe, southeast Asia, the Middle East ,Africa, South America and some other countries and areas.
We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team. We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional supplier in international market.
We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!
Metronidazole Basic information
| The nitro imidazoles antibiotics Chemical property Application Methods of production |
| Product Name: | Metronidazole |
| Synonyms: | 1-(2-Hydroxy-1-ethyl)-2-methyl-5-nitroimidazole;1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole;1-(beta-Hydroxyethyl)-2-methyl-5-nitroimidazole;1-(beta-Oxyethyl)-2-methyl-5-nitroimidazole;1H-Imidazole-1-ethanol, 2-methyl-5-nitro-;1H-Imidazole-1-ethanol,2-methyl-5-nitro-;1-Hydroxyethyl-2-methyl-5-nitroimidazole;2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethanol |
| CAS: | 443-48-1 |
| MF: | C6H9N3O3 |
| MW: | 171.15 |
| EINECS: | 207-136-1 |
| Product Categories: | Active Pharmaceutical Ingredients;API's;Peptide Synthesis/Antibiotics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;FLAGYL;antibiotic |
| Mol File: | 443-48-1.mol |
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| Metronidazole Chemical Properties |
| mp | 159-161 °C(lit.) |
| storage temp. | 2-8°C |
| solubility | acetic acid: 0.1 M, clear, faintly yellow |
| form | crystalline |
| Water Solubility | <0.1 g/100 mL at 20 ºC |
| Merck | 6157 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| NIST Chemistry Reference | Metronidazole(443-48-1) |
| EPA Substance Registry System | 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-(443-48-1) |
| Safety Information |
| Hazard Codes | Xn,T,F |
| Risk Statements | 40-46-45-39/23/24/25-23/24/25-11 |
| Safety Statements | 36/37-45-53-16-7 |
| WGK Germany | 3 |
| RTECS | NI5600000 |
| F | 8 |
| HS Code | 29332990 |
| Hazardous Substances Data | 443-48-1(Hazardous Substances Data) |
| Metronidazole Usage And Synthesis |
| The nitro imidazoles antibiotics |
Metronidazole is a kind of nitroimidazole antibiotics, also called flagyl, has killing effect on anaerobic microorganisms. When it restored in the body, its metabolites also have anti anaerobic bacteria, inhibiting the synthesis of bacterial deoxyribonucleic acid, thus interfering with bacterial growth, reproduction, and ultimately death of bacteria. And general anti anaerobic bacteria including: bacteroides fragilis, fusiform bacilli (it become well-known due to cell shape with sharp spindle shaped ends), tetanus, peptococcus, peptostreptococcus, giardia bacteria. At first, it was used in treatment of vaginal trichomoniasis, clinical effect is very significant. Later it was found that metronidazole can also kill anaerobic bacteria causing oral infection. In 1978, it was determined its anti anaerobic infection effects of drugs by the World Health Organization, widely used in the prevention and treatment of oral anaerobic bacteria infection in hospital. This products are also often used in the prevention and treatment for anaerobic bacteria causing respiratory tract, digestive tract, abdominal cavity and pelvic infection, skin and soft tissue and bone and joint infection, heart meningitis, septicemia and cerebral treatment. Metronidazole has significant effect on amoebiasis in vivo tissue and the intestines, also is the first choice drug for the treatment of toxoplasmosis in the human body, the mechanism is through inhibition of redox reaction of amoebae, rupturing protozoal nitrogen chain and functioned. In vitro test showed that, drug concentration is 1 ~ 2mg / L, soluble Entamoeba histolytica can change their shapes in 6 to 20 hours, and completely killed in 24 hours. The concentration is 0.2mg/L, can kill Entamoeba histolytica in 72 hours. It has been widely used in treatment of intestinal and extraintestinal amebiasis (such as amoebic liver abscess, pleural o Miba disease, etc.). Due to the interaction of nitroimidazole antibiotics, alcohol, nicotine, etc. and interference of ethanol oxidation process, can cause disulfiram reaction, resulting in rapid heart rate, decreasing blood pressure and other symptoms, so patients should be to avoid contact with alcoholic drink, smoke less, so as to avoid the occurrence of adverse drug reactions during treatment. The above information is edited by the Chemicalbook Hanya. |
| Chemical property | White or milky white crystalline powder. Melting point is 158-160. Soluble in hot water, slightly soluble in ethanol, slightly soluble in water or chloroform, slightly soluble in ether. Bitter and slightly salty. |
| Application |
1.In 1959, the goods were used for the treatment of vaginal trichomoniasis. Since 1970, it has used for the intestine, extraintestinal amebiasis, and it has high efficacy, low toxicity, wide application. it has mutagenic and teratogenic effects on experimental animals. 2.It has strong antibacterial effect on most anaerobic bacteria. 3.It is used for the treatment of amebiasis, trichomoniasis and anaerobic bacteria infection. |
| Methods of production | It is synthetized by 2-methyl-5-nitro imidazole (see 25010) and ethylene oxide addition. 2-methyl-5-nitro imidazole dissolved in formic acid and at 30-40℃ successive adding epoxy ethane, and sulfuric acid in the middle of adding feeding. and reaction for 1 h, after that. Decompression to recycle formic acid, water solution is cooled to 10 ℃, filter. The filtrate with sodium hydroxide solution to adjust pH = 10. Set aside to cool, filtering, washing to nearly alterations into neutral, recrystallization in water. Activated carbon decolorization to get metronidazole. |
| Chemical Properties | white to slightly yellow crystalline powder |
| Usage | Used as an antibacterial in the treatment of rosacea. Antiprotozoal (trichomonas). A potential human carcinogen. |
| General Description | White to pale-yellow crystalline powder with a slight odor. Bitter and saline taste. pH (saturated aqueous solution) about 6.5. |
| Air & Water Reactions | Insoluble in water. |
| Reactivity Profile | Metronidazole darkens on exposure to light. Metronidazole is incompatible with strong oxidizing agents. . |
| Fire Hazard | Flash point data for Metronidazole are not available; however, Metronidazole is probably combustible. |
| Metronidazole Preparation Products And Raw materials |
| Raw materials | Glyoxal-->Acetaldehyde-->BENZANILIDE-->2-Methylimidazole-->2-Methyl-5-nitroimidazole |
