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CAS NO.32222-06-3
1(10-100)Gram1(100-200)Gram
| Calcitriol Basic information |
| Product Name: | Calcitriol |
| Synonyms: | VITAMIN D3, 1ALPHA,25-DIHYDROXY;(5z,7e)-(1s,3r)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol;9,10-SECOCHOLESTA-5Z,7E,10(19)-TRIENE-1ALPHA,3BETA,25-TRIOL;1,25-(OH)2-D3;(1ALPHA,3BETA,5Z,7E)-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL;1ALPHA,25-DIHYDROXYCHOLECALCIFEROL;1ALPHA,25-DIHYDROXYVITAMIN D3;1ALPHA,25-DIHYDROXY-VITAMIN D8 |
| CAS: | 32222-06-3 |
| MF: | C27H44O3 |
| MW: | 416.64 |
| EINECS: | 250-963-8 |
| Product Categories: | Miscellaneous Biochemicals;Vitamin D3 analogs;API;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Isolabel;reagent;standard substance;Inhibitors |
| Mol File: | 32222-06-3.mol |
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| Calcitriol Chemical Properties |
| mp | 119-1210C |
| Fp | 14 °C |
| storage temp. | 2-8°C |
| Stability: | Air and Light Sensitive |
| CAS DataBase Reference | 32222-06-3(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | T+,Xn,F |
| Risk Statements | 26/27/28-63-36/37/38-20/21/22-11 |
| Safety Statements | 36/37/39-45-36-26-16-7 |
| RIDADR | UN 2811 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | FZ4645000 |
| F | 8-10-19 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
| HS Code | 29061900 |
| Hazardous Substances Data | 32222-06-3(Hazardous Substances Data) |
| MSDS Information |
| Provider | Language |
|---|---|
| 1alpha,25-Dihydroxycholecalciferol | English |
| SigmaAldrich | English |
| Calcitriol Usage And Synthesis |
| Physiological function |
Calcitriol is the active form of vitamin D and is also a kind of hormones in the body. It plays an important role in the regulation of calcium and phosphorus concentration. It can increase the blood calcium level by increasing the intestinal absorption of calcium and can also increase the release of the bone calcium release for increasing the blood calcium levels. This study was first conducted and reported by Michael F. Holick in 1971. The basic principle of action model of calcitriol in many cases is through binding with the vitamin D receptor (the VDR), e.g., the ligand-receptor complex forming between calcitriol and its receptor in the intestinal epithelial cells cytoplasm can be transferred to the nucleus for being as the transcriptional factor in promoting the expression of calcium-binding protein. The increased level of calcium-binding proteins can help the cell to actively transport of more calcium ions, thereby increasing the calcium absorption level. Calcium absorption while maintaining electrical neutrality also requires transporting anions, mainly the absorption of inorganic phosphate ions, so calcitriol also promote the absorption of phosphorus. Clinically, this drug can be used in the treatment of hypocalcemia, hypoparathyroidism (adult), osteomalacia, rickets (infants), chronic kidney disease, renal osteodystrophy, osteoporosis, as well as the prevention of glucocorticoid induced osteoporosis. Calcitriol-dimensional molecular structure The above information is edited by the chemicalbook of Dai Xiongfeng. |
| Application | Vitamin medicines; it can be used for treating the renal bone malnutrition of patients with chronic renal failure; |
| Category | toxic substances |
| Toxicity grading | highly toxic |
| Acute toxicity | oral - rat LD50 0.62 mg / kg; Oral - Mouse LD50: 1.35 mg / kg |
| Flammability and hazard characteristics | flammable with the fire releasing acrid smoke |
| Storage characteristics | Treasury: ventilation, low-temperature and drying; store it separately from food |
| Extinguishing agent | water, sand |
| Chemical Properties | White Crystalline Powder |
| Usage | The biologically active form of vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriatic |
| Usage | Calcium regulator, anti-psoriatic |
| Biological Activity | Active metabolite of vitamin D 3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca 2+ absorption and regulates bone Ca 2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells. |
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