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CAS NO.320-67-2
| 5-Azacytidine Basic information |
| Product Name: | 5-Azacytidine |
| Synonyms: | 4-amino-1-beta-d-ribofuranosyl-s-triazin-2(1h)-on;5-triazin-2(1h)-one,4-amino-1-beta-d-ribofuranosyl-3;antibioticu18496;mylosar;nci-c01569;nsc-102816;u18496;5-AZAC |
| CAS: | 320-67-2 |
| MF: | C8H12N4O5 |
| MW: | 244.2 |
| EINECS: | 206-280-2 |
| Product Categories: | API intermediates;Antitumors for Research and Experimental Use;Biochemistry;Chemical Reagents for Pharmacology Research;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents;Bases & Related Reagents;Nucleotides;Carbohydrates & Derivatives;Epigenetics;Pyrimidine purine;5-azacytidine, Mylosar, Ladakamycin;CORVATON;Inhibitors |
| Mol File: | 320-67-2.mol |
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| 5-Azacytidine Chemical Properties |
| mp | 226-232 °C (dec.)(lit.) |
| alpha | 40 º (C=1, H2O 22 ºC) |
| storage temp. | 2-8°C |
| form | lyophilized powder |
| Water Solubility | 0.5-1.0 g/100 mL at 21 ºC |
| Merck | 887 |
| CAS DataBase Reference | 320-67-2(CAS DataBase Reference) |
| EPA Substance Registry System | 1,3,5-Triazin-2( 1H)-one, 4-amino-1-.beta.-D-ribofuranosyl- (320-67-2) |
| Safety Information |
| Hazard Codes | T |
| Risk Statements | 45-46-22 |
| Safety Statements | 53-22-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | XZ3017500 |
| F | 10-23 |
| Hazardous Substances Data | 320-67-2(Hazardous Substances Data) |
| MSDS Information |
| Provider | Language |
|---|---|
| 5-Azacytidine | English |
| ACROS | English |
| SigmaAldrich | English |
| 5-Azacytidine Usage And Synthesis |
| Chemical Properties | White-to-Off-White Crystalline Solid |
| Usage | A potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase |
| Usage | Antineoplastic;'Antimetabolite |
| Usage | antianginal |
| General Description | White crystalline powder. |
| Air & Water Reactions | Slightly water soluble. Unstable in solution. |
| Reactivity Profile | 5-Azacytidine is sensitive to light (may discolor). 5-Azacytidine is sensitive to oxidation. 5-Azacytidine is unstable in solution. 5-Azacytidine undergoes hydrolysis in aqueous buffers. 5-Azacytidine is incompatible with strong oxidizers. |
| Fire Hazard | Flash point data for 5-Azacytidine are not available; however, 5-Azacytidine is probably combustible. |
| Biological Activity | DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells. |
5-azacytidine :
Chemical Name: 4-Amino-1-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
CAS No.: 320-67-2
Molecular formula: C8H12N4O5
Molecular weight: 244.20
Standard: company standard
Structure formula:
