HENAN SUNLAKE ENTERPRISE CORPORATION
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Tel: 86-371-86259723
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Tel: +86-371- 86259723
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CAS NO.3093-35-4
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
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About Company
| Product Name: | Halcinonide |
| Synonyms: | 20-dione,21-chloro-9-fluoro-11-beta,16-alpha,17-trihydroxy-pregn-4-ene-cyc;halciderm;halcimat;halcort;halog;lic16,17-acetalwithacetone;(11b,16a)-21-chloro-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregn-4-ene-3,20-dione;HALCINONIDE |
| CAS: | 3093-35-4 |
| MF: | C24H32ClFO5 |
| MW: | 454.96 |
| EINECS: | 221-439-6 |
| Product Categories: | Organics;Cortisone;Hormones;Steroid Hormones;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;API |
| Mol File: | 3093-35-4.mol |
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| Halcinonide Chemical Properties |
| CAS DataBase Reference | 3093-35-4(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 63 |
| Safety Statements | 36 |
| WGK Germany | 3 |
| RTECS | TU5010200 |
| MSDS Information |
| Provider | Language |
|---|---|
| (11b,16a)-21-Chloro-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregn-4-ene-3,20-dione | English |
| SigmaAldrich | English |
| Halcinonide Usage And Synthesis |
| Outline | Halcinonide is an efficient synthetic fluorine and chlorine corticosteroid, the effect of it is similar to fludrocortisone . It has strong anti-inflammatory, anti-allergic, anti-itching, inhibiting proliferation of immune effects, topical application can reduce the permeability of the capillary wall and cell membrane,and reduce the inflammatory exudate, and inhibit histamine and other inflammatory mediators formation and release.it is clinically used for subacute or chronic non-infectious skin diseases such as psoriasis, eczema, neurodermatitis, contact dermatitis, seborrheic dermatitis (non-face), atopic dermatitis, flat moss and discoid lupus erythematosus and the like which are hormone therapy ineffective . |
| Physical and Chemical Properties |
White or off-white crystalline powder, odorless. Almost insoluble in water, slightly soluble in ethanol or methanol, soluble in acetone and chloroform. Sealed. |
| Pharmacological effects |
This drug is a potent synthetic glucocorticoid ,its action is similar to fludrocortisone. It has strong anti-inflammatory, anti-allergic, anti-itching, inhibit proliferation of immune and other effects, topical application are unlikely to cause systemic adverse reactions. The drug has the same effect of inhibiting the proliferation of granulation tissue as dexamethasone ,it is stronger than hydrocortisone. The drug is not substantially absorbed in external skin, it has no irritating effect on the body. The extent of absorption of topical application is hugely different among anatomic sites: forearm 1%, 4% of the scalp, forehead, 7%, 36% of the scrotum, the greatest penetration is in the groin, armpits and face. The drug is mainly metabolized in the liver, it is mostly excreted by the kidneys, and less by biliary excretion. The above information is edited by the chemicalbook of Tian Ye. |
| Indications | The drug is suitable for treatment of contact dermatitis, atopic dermatitis, lichen,the small size of psoriasis, lichen, heat rash, genital atrophic lichen sclerosus, non-parasitic prurigo, ring granuloma, discoid lupus erythematosus, non-facial seborrheic dermatitis, mycosis fungoides pruritus symptomatic .It is also used for the treatment of insect bites, parasitic prurigo through specific treatment. It has a good effect on the treatment of psoriasis . |
| Adverse reactions |
1. There are a small number of patients whose applicator parts of the skin occurs burning, stinging, itching temporary, long-term use can occur telangiectasia skin (especially face), skin atrophy, stretch marks (teenagers prone), fragile skin, hirsutism, folliculitis, milia, skin bleaching, delayed ulcer healing, packet method in skin folds easily causes fungal infection. 2. When it is much absorbed through the skin, it can cause systemic adverse reactions. |
| Contraindications |
1.Patients who are allergic to this drug and adrenal corticosteroids are banned. 2. The primary skin diseases , exudative dermatitis, ulcerative lesions, acne, rosacea caused by bacteria, fungi, viruses and parasites are banned. 3. It is forbidden using in the eyelid portion (cause a risk of glaucoma). |
| Precautions |
1. The large area of large quantities of drugs or medication packet mode allow more amount of the drug being absorbed through the skin, which causes systemic reactions, especially in young children and infants, it can cause reversible Cushing's syndrome and growth retardation, sudden withdrawal can cause acute adrenal insufficiency. 2. When the local intolerance phenomena occurs,the drug should be stopped and the reason should be found. 3. It should be paid attention that drug staying in the skin folds and diaper can be absorbed into the body. |
| Specification | Ointments, creams, solutions: 0.1%. |
| Application | Cortical hormone drugs for the treatment of psoriasis and eczema dermatitis . |
| Usage | Anti-inflammatory (topical). |
| Halcinonide Preparation Products And Raw materials |