Product information

Atenolol Basic information

Pharmacological Affects Chemical Property Application

Product Name:	Atenolol
Synonyms:	noten;(RS)-ATENOLOL;(RS)-4-[2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPOXY]BENZENEACETAMIDE;TENORMIN;tenlol;1-p-carbamoylmethylphenoxy-3-isopropylamino-2-propanol;2-(p-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)-acetamid;2-(p-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide
CAS:	29122-68-7
MF:	C14H22N2O3
MW:	266.34
EINECS:	249-451-7
Product Categories:	Pharmaceutical;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Adrenoceptor;Amines;Aromatics;API;Isotope;TENORMIN;Other APIs
Mol File:	29122-68-7.mol

Atenolol Chemical Properties

mp	154°C
storage temp.	Store at RT
solubility	H2O: 0.3 mg/mL
form	powder
color	white to off-white
Merck	859
CAS DataBase Reference	29122-68-7(CAS DataBase Reference)
NIST Chemistry Reference	Atenolol(29122-68-7)

Safety Information

Hazard Codes	Xn,F
Risk Statements	22-36/37/38-20/21/22-36-11
Safety Statements	22-24/25-36-26-36/37-16
WGK Germany	2
RTECS	AC3600000
HazardClass	IRRITANT
HS Code	29242995
Hazardous Substances Data	29122-68-7(Hazardous Substances Data)

MSDS Information

Provider	Language
Tenormin	English
SigmaAldrich	English

Atenolol Usage And Synthesis

Pharmacological Affects	Atenolol ,also known as atenolol, Aten Yue Er, tamoxifen, downhill Ling blood pressure, Tenormin, blood pressure Ling, is a long-acting cardioselective β1-adrenergic blockers, without intrinsic sympathomimetic activity or membrane stability.The atenolol,s retardation for β1 adrenaline receptors is similar with metoprolol, propranolol and nadolol , which is 1/6 times for pindolol and timolol. But, it does not inhibit the effect of the isoproterenol bronchodilator.When administered in small doses, it does not like non-selective β-adrenergic blockers as aggravated hypoglycemia induced hypertensive crisis, peripheral circulatory impairment or patients with obstructive airways disease worsening airway function and so on. However, When administered in large doses, atenolol also can decrease asthma or chronic obstructive pulmonary disease, airway function. Atenolol, as a long-term treatment of hypertension, also were reported for affecting airway function. Thus, despite atenolol heart selection, chronic obstructive pulmonary disease patients can only use small doses, but also should be given a sufficient amount of β1-adrenergic receptor agonists.  Oral F is 46% ~ 60%, Tmax about 2 ~ 4 h, Mainly unchanged since the urine excretion, T1 / 2 of 6 ~ 7 h. Hemodialysis can clear the goods. Rapidly absorbed from the gastrointestinal tract, but not exclusively.The rest of the body is excreted in the stool. Food can reduce the F, fasting and after meals AUC decreased by 20%. Distribution of the central nervous system is relatively few. The ratio of brain tissue to blood concentration was 0.1:1. Easy to achieve in the placenta and the maternal plasma concentrations of same. PPB is less than 5%, Vd is 50 ~ 75 L. Atenolol is not metabolized by the liver, most of the drug is excreted from the body in urine, renal insufficiency in patients with T1 / 2 was significantly prolonged. Patients with renal failure range of T1 / 2 was 10 ~ 28 h, or even up to 100 h. Results at 24 h after, the discharge from the urine of the drug can be reduced by 29%. The T1/2 of patients with hyperthyroidism was significantly shortened, 4.2h.  The above information is edited by the chemicalbook of Kui Ming.
Chemical Property	White powder. Melting point (146-148 ℃). Soluble in alcohol, slightly soluble in water, chloroform, Hardly soluble in ethyl ether, slightly smelly.
Application	β-blockers. Clinical application in the treatment of hypertension, angina and arrhythmia.
Chemical Properties	Crystalline Solid
Usage	Cardioselective adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II)
Usage	Cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II).
Usage	beta adrenergic blocker
Usage	Selective b1 adrenergic receptor agonist, anti-hypertensive, anti-anginal, anti-arrhythmic
Usage	Antihypertensive, Beta-adrenoceptor antagonist
Biological Activity	Cardioselective β -adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic.

Company Information

 Henan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .

  Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs ,  Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East ,  Africa , South America and some other countries and areas.

    We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you  better with our high - quality products and professional team.

    We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.

    We  welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate.