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Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
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Tel: +86-371- 86259723
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CAS NO.220127-57-1
1(10-100)Gram1(100-200)Gram
| Imatinib mesylate Basic information |
| Product Name: | Imatinib mesylate |
| Synonyms: | GLIVEC;GLEEVEC;IMATINIB METHANESULFONATE;CGP-57148B;4-[(4-methylpiperazin-1-yl)methyl]-n-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide methanesulfonate;4-[(4-methyl-1-piperazinyl)methyl]-n-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide monomethanesulfonate;STI-571;IMATINIB BASE(IMA-3) |
| CAS: | 220127-57-1 |
| MF: | C30H35N7O4S |
| MW: | 589.71 |
| EINECS: | |
| Product Categories: | Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Tyrosine Kinase Inhibitors;Aromatics;Heterocycles;API;Glivec, CGP-57148B, STI-571;Antineoplastic;Anti-cancer&immunity;Inhibitors |
| Mol File: | 220127-57-1.mol |
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| Imatinib mesylate Chemical Properties |
| mp | 214-224°C |
| storage temp. | -20°C Freezer |
| CAS DataBase Reference | 220127-57-1(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Hazardous Substances Data | 220127-57-1(Hazardous Substances Data) |
| Imatinib mesylate Usage And Synthesis |
| a small-molecule inhibitor |
Imatinib mesylate (also called Gleevec) is a small-molecule inhibitor of the fusion protein Bcr-Abl, the causal agent in chronic myelogenous leukemia. As an inhibitor of PDGFR, imatinib mesylate appears to have utility in the treatment of a variety of dermatological diseases. Imatinib has been reported to be an effective treatment for FIP1L1-PDGFRalpha+ mast cell disease, hypereosinophilic syndrome, and dermatofibrosarcoma protuberans. |
| Chemical Properties | Off-White Solid |
| Usage | A tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL) |
| Usage | Imatinib Mesylate is orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively. Imatinib also known as Gleevec, Glivec, CGP-57148B, STI-571 & Imatinib |
| Usage | Imatinib Mesylate (STI571) is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively. |
| Usage | echinocandin antifungal, active against infections with Aspergillus and Candida, inhibits cell wall synthesis |
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