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Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
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Tel: +86-371- 86259723
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CAS NO.18378-89-7
| MITHRAMYCIN A Basic information |
| Product Name: | MITHRAMYCIN A |
| Synonyms: | AUREOLIC ACID;METHRAMYCIN A;MITHRACIN;MITHRAMYCIN;MITHRAMYCIN A;MITHRAMYCIN A, STREPTOMYCES PLICATUS;PLICAMYCIN;(2s-alpha,3beta(1r*,3r*4s*)))-droxy-7-methyl |
| CAS: | 18378-89-7 |
| MF: | C52H76O24 |
| MW: | 1085.15 |
| EINECS: | 232-455-8 |
| Product Categories: | Antibiotics;Antitumour;antibiotic |
| Mol File: | 18378-89-7.mol |
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| MITHRAMYCIN A Chemical Properties |
| Melting point | 180-183 °C |
| storage temp. | 2-8°C |
| Merck | 13,7619 |
| Safety Information |
| Hazard Codes | Xn,T+ |
| Risk Statements | 22-26/27/28 |
| Safety Statements | 45-38-36/37/39-28A-22 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | PZ2800000 |
| F | 10 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| MITHRAMYCIN A Usage And Synthesis |
| Chemical Properties | yellow powder |
| Usage | Transcription inhibitor |
| Usage | Mithramycin was the first of the aureolic acid class of antitumour antibiotics, isolated from Streptomyces. Mithramycin inhibits transcription and protein synthesis by non-covalent binding with G-C-rich duplex DNA in the presence of magnesium and zinc ions. Mithramycin also induces differentiation of leukemic cells accompanied by an early decrease in c-myc expression, and selectively inhibits collagen-1 gene expression in human fibroblasts. |
| Usage | Mithramycin A was the first of the aureolic acid class of antitumor antibiotics, isolated from Streptomyces. Mithramycin inhibits transcription and protein synthesis by non-covalent binding with G-C-rich duplex DNA in the presence of magnesium and zinc ions. Mithramycin also induces differentiation of leukemic cells accompanied by an early decrease in c-myc expression, and selectively inhibits collagen-1 gene expression in human fibroblasts. |
| Biological Activity | Anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg 2+ or Zn 2+ , inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells. |
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