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CAS NO.179324-69-7
1(10-100)Gram1(100-200)Gram
| Bortezomib Basic information |
| Product Name: | Bortezomib |
| Synonyms: | VELCADE;dpba;BORTEZOMIB;[(1r)-3-methyl-1-[[(2s)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-boronic acid;VELCADE(BORTEZOMIB);Boronic acid, B-[(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]-;Bortezomib for research;Bortezomib ( Velcade, MG-341, PS-341 ) |
| CAS: | 179324-69-7 |
| MF: | C19H25BN4O4 |
| MW: | 384.24 |
| EINECS: | |
| Product Categories: | Boron Derivatives;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Pepetides;ProteasomeInhibitors;Apis;Inhibitor;Final material;API;peptides |
| Mol File: | 179324-69-7.mol |
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| Bortezomib Chemical Properties |
| mp | 122-124°C |
| density | 1.214 |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| Stability: | Hygroscopic and Moisture Sensitive |
| CAS DataBase Reference | 179324-69-7(CAS DataBase Reference) |
| Safety Information |
| Hazardous Substances Data | 179324-69-7(Hazardous Substances Data) |
| Bortezomib Usage And Synthesis |
| Drug for Cancer treatment |
Bortezomib is a drug for treatment of hematopoietic malignancies with the appearance being white or white-like crystalline powder. It is easily soluble in dimethyl sulfoxide, ethanol, but insoluble in aqueous solution. This product is the reversible inhibitor of the mammal cell 26S proteasome chymotrypsin-like activity. 26S proteasome is a large protein complex which can degrade ubiquitin. Ubiquitin proteasome pathway plays an important role in regulation of the intracellular concentration of specific proteins in order to maintain the stability of the intracellular environment. Proteolytic affects intracellular multi-level signalling cascade. The disruption of the normal intracellular environment can lead to cell death while the inhibition of the 26S proteasome can prevent the hydrolysis of specific proteins. In vitro tests have proved bortezomib exhibits cytotoxicity to multiple types of cancer cells. The in vivo models of preclinical tumor have proved that bortezomib is capable of delaying the tumor growth of multiple myeloma which is suitable for the treatment of multiple myeloma. The above information is edited by the Chemicalbook of Dai Xiongfeng. |
| Chemical Properties | Yellow Solid |
| Usage | Bortezomib is the first proteasome inhibitor to be approved b the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. T |
| Usage | Bortezomib is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle foun d in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway. |
| Usage | selective proteasome inhibitor |
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