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Tel: 17734809689
Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
Mobile: 17734809689
Tel: +86-371- 86259723
Fax: +86-371- 86259723
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CAS NO.17374-26-4
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
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Product Name: | 4,5,6,7-TETRABROMOBENZOTRIAZOLE |
Synonyms: | NSC 231634;TBB;TBBT;4,5,6,7-TETRABROMO-2-AZABENZIMIDAZOLE;4,5,6,7-TETRABROMOBENZOTRIAZOLE;CASEIN KINASE II INHIBITOR I;CK2 INHIBITOR;4,5,6,7-Tetrabromotriazole |
CAS: | 17374-26-4 |
MF: | C6HBr4N3 |
MW: | 434.71 |
EINECS: | |
Product Categories: | Protein Kinase Inhibitors and Activators;Protein Kinase;PI3K/Akt/mTOR;Inhibitors |
Mol File: | 17374-26-4.mol |
4,5,6,7-TETRABROMOBENZOTRIAZOLE Chemical Properties |
mp | 262-266°C |
storage temp. | 2-8°C |
solubility | DMSO: 28 mg/mL |
form | solid |
color | white |
Safety Information |
WGK Germany | 3 |
MSDS Information |
Provider | Language |
---|---|
SigmaAldrich | English |
4,5,6,7-TETRABROMOBENZOTRIAZOLE Usage And Synthesis |
Chemical Properties | Crystalline Solid |
Usage | TBB is one of the most selective protein kinase inhibitors known, and when tested against a panel of 33 serine/threonine and tyrosine protein kinases, only three exhibited moderate inhibition by TBB, with Ki values one to two orders of magnitude higher than that for CK2. |
Biological Activity | A cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC 50 = 0.9 and 1.6 μ M for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with K i values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases. |
4,5,6,7-TETRABROMOBENZOTRIAZOLE Preparation Products And Raw materials |