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CAS NO.15663-27-1
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| Cisplatin Basic information |
| Product Name: | Cisplatin |
| Synonyms: | LEDERPLATIN;BRIPLATIN;DIAMMINEDICHLOROPLATINATE (II);CPDC;CISMAPLAT;CISPLATIIN;CISPLATIN DIHYDROCHLORIDE;CISPLATIN |
| CAS: | 15663-27-1 |
| MF: | Cl2H6N2Pt |
| MW: | 300.05 |
| EINECS: | 239-733-8 |
| Product Categories: | Pharmaceutical material and intermeidates;Active Pharmaceutical Ingredients;Antitumors for Research and Experimental Use;Biochemistry;Classes of Metal Compounds;Pt (Platinum) Compounds;Transition Metal Compounds;Intermediates & Fine Chemicals;Pharmaceuticals;Caspases/Apoptosis;anti cancer;ammine metal halide;Anti Cancer Reagents;chemical reaction,pharm,electronic,materials;Anti-cancer&immunity;Inhibitors |
| Mol File: | 15663-27-1.mol |
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| Cisplatin Chemical Properties |
| mp | 340 °C (dec.)(lit.) |
| density | 3,7 g/cm3 |
| storage temp. | Store at RT |
| form | crystalline |
| color | yellow |
| Water Solubility | <0.1 g/100 mL at 19 ºC |
| Merck | 14,2317 |
| Stability: | Stable. Incompatible with oxidizing agents, aluminium, antioxidants. |
| CAS DataBase Reference | 15663-27-1(CAS DataBase Reference) |
| EPA Substance Registry System | Platinum, diamminedichloro-, (SP-4-2)-(15663-27-1) |
| Safety Information |
| Hazard Codes | T |
| Risk Statements | 45-25-41-60-46-42/43-36/37/38 |
| Safety Statements | 53-26-39-45-99-36/37/39-22 |
| RIDADR | UN 3288 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | TP2455000 |
| F | 10-21 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| Hazardous Substances Data | 15663-27-1(Hazardous Substances Data) |
| Cisplatin Usage And Synthesis |
| Chemical Properties | Crystalline |
| Usage | muscle relaxant (skeletal) |
| Usage | antitumor agent |
| Usage | Used as an antineoplastic |
| General Description | An anticancer drug. Orange-yellow to deep yellow solid or powder. |
| Air & Water Reactions | Insoluble in water. |
| Reactivity Profile | Cisplatin is incompatible with oxidizing agents. Cisplatin is also incompatible with aluminum. Cisplatin may react with sodium bisulfite and other antioxidants. |
| Fire Hazard | Flash point data for Cisplatin are not available; however, Cisplatin is probably combustible. |
| Biological Activity | Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF- α -induced apoptosis. |