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CAS NO.1508-75-4
1(10-100)Kilogram1(100-500)Kilogram2(500-1000)Kilogram
1. Certificate Of Analysis (COA)
2. Material Safety Data Sheet (MSDS)
3. Route of synthesis (ROS)
4. Method of Aanlysis (MOA)
5. Nuclear Magnetic Resonance (NMR)
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| Tropicamide Basic information |
| Ophthalmic drugs Application |
| Product Name: | Tropicamide |
| Synonyms: | Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-;bistropamide;component of Paremyd;epitromina;Mydriacyl;mydriat;mydrin;mydrum |
| CAS: | 1508-75-4 |
| MF: | C17H20N2O2 |
| MW: | 284.35 |
| EINECS: | 216-140-2 |
| Product Categories: | Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Acetylcholine receptor;Inhibitors |
| Mol File: | 1508-75-4.mol |
|
|
|
| Tropicamide Chemical Properties |
| mp | 98 °C |
| storage temp. | 2-8°C |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.3 mg/mL |
| form | solid |
| color | white |
| Merck | 9780 |
| CAS DataBase Reference | 1508-75-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Tropicamide(1508-75-4) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 20/21/22-36/37/38-42/43-41-37/38-22 |
| Safety Statements | 22-26-36-36/37/39 |
| WGK Germany | 3 |
| RTECS | CY1487860 |
| MSDS Information |
| Provider | Language |
|---|---|
| N-Ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide | English |
| SigmaAldrich | English |
| Tropicamide Usage And Synthesis |
| Ophthalmic drugs |
Tropicamide is an anticholinergic agent. At room temperature, it is a white crystalline powder and is odorless. It is slightly soluble in water and easily soluble in ethanol, dilute hydrochloric acid, sulfuric acid and chloroform. It can block the excitement of iris sphincter and ciliary muscle induced by acetylcholine. Its 0.5% solution can cause mydriasis while its 1% solution can cause ciliary muscle paralysis and mydriasis. Clinically it is mainly used for the treatment of eye drops mydriasis and paralysis. Tropicamide is the synthetic derivative of tropic acid. It has a relative low dissociation constant with good intraocular permeability and strong tissue diffusion capability which may be the underlying mechanism for its quick onset but short maintaining time. After the drop of the 0.5% or 1% solution of this product, the instillation dilation and paralysis adjustment can reach peak within 20-30 minutes. Then the effect gradually decreases with adjusting paralysis (residual) for 2 to 6 hours and mydriasis (residual) for about 7 hours. Tropicamide is similar drug as atropine which can cause a dramatic increase on the angle closure glaucoma intraocular pressure as well as possibly stimulate undiagnosed angle-closure glaucoma. The potency of ciliary muscle paralysis adjustment of tropicamide eye drops is closely related with the doses used, its 0.25%, 0.5%, 0.75% and 1% four concentrations can all adjust paralysis. After instillation, the maximum degree of residual adjustment is 0.25%: diopter: 3.17; 1% diopter: 3.17. The residue adjustment degree can be maintained in cases of the refraction being 2.0 or less, 0.75% and 1% solutions can maintain for 40 minutes while 0.5% can only maintain about 15 minutes. After a drop of 1% solution, have the second drop after 5 to 25 minutes and by doing this, we can get more satisfactory ciliary muscle paralysis effect for about 20 to 30 minutes. After 2 to 6 hours, you can read books and newspapers with the adjustment function being able to recover to the level before drop within 6 hours. The above information is edited by the Chemicalbook of Dai Xiongfeng. |
| Application |
It can be used as an anti-cholinergic drugs or mydriatic drug. It is a kind of M4 muscarinic acetylcholine receptor antagonist. |
| Chemical Properties | Crystalline Solid |
| Usage | antidepressant, nutrient; LD50(rat) 1634 mg/kg ip |
| Usage | Indicated to induce mydriasis (dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle of the eye) in diagnostic procedures, such as measurement of refractive errors and examination of the fundus of the eye. |
| Usage | Ophthalmic anticholinergic. Mydriatic |
| Biological Activity | M 4 selective muscarinic receptor antagonist. |
| Tropicamide Basic information |
| Ophthalmic drugs Application |
| Product Name: | Tropicamide |
| Synonyms: | Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-;bistropamide;component of Paremyd;epitromina;Mydriacyl;mydriat;mydrin;mydrum |
| CAS: | 1508-75-4 |
| MF: | C17H20N2O2 |
| MW: | 284.35 |
| EINECS: | 216-140-2 |
| Product Categories: | Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Acetylcholine receptor;Inhibitors |
| Mol File: | 1508-75-4.mol |
|
|
|
| Tropicamide Chemical Properties |
| mp | 98 °C |
| storage temp. | 2-8°C |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.3 mg/mL |
| form | solid |
| color | white |
| Merck | 9780 |
| CAS DataBase Reference | 1508-75-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Tropicamide(1508-75-4) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 20/21/22-36/37/38-42/43-41-37/38-22 |
| Safety Statements | 22-26-36-36/37/39 |
| WGK Germany | 3 |
| RTECS | CY1487860 |
| MSDS Information |
| Provider | Language |
|---|---|
| N-Ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide | English |
| SigmaAldrich | English |
| Tropicamide Usage And Synthesis |
| Ophthalmic drugs |
Tropicamide is an anticholinergic agent. At room temperature, it is a white crystalline powder and is odorless. It is slightly soluble in water and easily soluble in ethanol, dilute hydrochloric acid, sulfuric acid and chloroform. It can block the excitement of iris sphincter and ciliary muscle induced by acetylcholine. Its 0.5% solution can cause mydriasis while its 1% solution can cause ciliary muscle paralysis and mydriasis. Clinically it is mainly used for the treatment of eye drops mydriasis and paralysis. Tropicamide is the synthetic derivative of tropic acid. It has a relative low dissociation constant with good intraocular permeability and strong tissue diffusion capability which may be the underlying mechanism for its quick onset but short maintaining time. After the drop of the 0.5% or 1% solution of this product, the instillation dilation and paralysis adjustment can reach peak within 20-30 minutes. Then the effect gradually decreases with adjusting paralysis (residual) for 2 to 6 hours and mydriasis (residual) for about 7 hours. Tropicamide is similar drug as atropine which can cause a dramatic increase on the angle closure glaucoma intraocular pressure as well as possibly stimulate undiagnosed angle-closure glaucoma. The potency of ciliary muscle paralysis adjustment of tropicamide eye drops is closely related with the doses used, its 0.25%, 0.5%, 0.75% and 1% four concentrations can all adjust paralysis. After instillation, the maximum degree of residual adjustment is 0.25%: diopter: 3.17; 1% diopter: 3.17. The residue adjustment degree can be maintained in cases of the refraction being 2.0 or less, 0.75% and 1% solutions can maintain for 40 minutes while 0.5% can only maintain about 15 minutes. After a drop of 1% solution, have the second drop after 5 to 25 minutes and by doing this, we can get more satisfactory ciliary muscle paralysis effect for about 20 to 30 minutes. After 2 to 6 hours, you can read books and newspapers with the adjustment function being able to recover to the level before drop within 6 hours. The above information is edited by the Chemicalbook of Dai Xiongfeng. |
| Application |
It can be used as an anti-cholinergic drugs or mydriatic drug. It is a kind of M4 muscarinic acetylcholine receptor antagonist. |
| Chemical Properties | Crystalline Solid |
| Usage | antidepressant, nutrient; LD50(rat) 1634 mg/kg ip |
| Usage | Indicated to induce mydriasis (dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle of the eye) in diagnostic procedures, such as measurement of refractive errors and examination of the fundus of the eye. |
| Usage | Ophthalmic anticholinergic. Mydriatic |
| Biological Activity | M 4 selective muscarinic receptor antagonist. |