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CAS NO.134523-03-8
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| Atorvastatin calcium Basic information |
| Product Name: | Atorvastatin calcium |
| Synonyms: | LIPITOR;ATORVASTATIN CALCIUM SALT;ATORVASTATIN CALCIUM;ATORVASTATIN CA;[r-(r*, r*)]-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylaminocarbonyl)-1h-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid calcium salt;1h-pyrrole-1-heptanoicacid,beta,delta-dihydroxy-2-(4-fluorophenyl)-5-(1-methy;calciumsalt(2:1),(r-(r*,r*))-lethyl)-3-phenyl-4-((phenylamino)carbonyl);ci-981 |
| CAS: | 134523-03-8 |
| MF: | C66H68CaF2N4O10 |
| MW: | 1155.36 |
| EINECS: | 200-659-6 |
| Product Categories: | Active Pharmaceutical Ingredients;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Atorvastatin;Aromatics;Chiral Reagents;Pfizer compounds;Pharmaceutical intermediates;Isotope;LIPITOR;Cardiovascular APIs;Antilipemic agent;API |
| Mol File: | 134523-03-8.mol |
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| Atorvastatin calcium Chemical Properties |
| mp | 176-178°C |
| storage temp. | Store at +4°C |
| CAS DataBase Reference | 134523-03-8(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn,T,F |
| Risk Statements | 20/21/22-36/37/38-39/23/24/25-23/24/25-11 |
| Safety Statements | 26-36-45-36/37-16-7 |
| Atorvastatin calcium Usage And Synthesis |
| Chemical Properties | White Crystalline Powder |
| Usage | A selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia |
| Usage | A selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia. |
| Usage | antihyperlipidemic, HMGCoA reductase inhibitor |
| Usage | DMSO and EtOH soluble |
| Usage | The primary uses of atorvastatin is for the treatment of dyslipidemia and the prevention of cardiovascular disease. |
| Biological Activity | Potent HMG-CoA reductase inhibitor (IC 50 = 8 nM). Reduces circulating LDL-C by inhibiting cholesterol biosynthesis and inducing expression of LDL receptors. Inhibits smooth muscle cell proliferation in vitro and exhibits antinociceptive effects in the inflammatory hypernociception model. |