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CAS NO.1300031-49-5
1(10-100)Metric Ton1(10-100)Metric Ton
| I-BET151 (GSK1210151A) Basic information |
| Product Name: | I-BET151 (GSK1210151A) |
| Synonyms: | 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydro-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one;GSK 1210151A;I-BET 151;I-BET 151/GSK 1210151A;GSK1210151A (I-BET151);7-(3,5-diMethylisoxazol-4-yl)-8-Methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-iMidazo[4,5-c]quinolin-2(3H)-one;7-(3,5-Dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2;7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydro-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one I-BET151(GSK1210151A) |
| CAS: | 1300031-49-5 |
| MF: | C23H21N5O3 |
| MW: | 415.44454 |
| EINECS: | |
| Product Categories: | Inhibitors |
| Mol File: | 1300031-49-5.mol |
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| I-BET151 (GSK1210151A) Chemical Properties |
| density | 1.314 |
| storage temp. | 2-8°C |
| I-BET151 (GSK1210151A) Usage And Synthesis |
| Chemical Properties | Off-White Solid |
| Usage | I-BET 151 is part of a novel series of quinoline isoxazole BET family bromodomain inhibitors, a family of four proteins that selectively bind to aceylated lysine residues in histone. I-BET 151 play ke y roles in many cellular processes, including anti-inflammatory gene expression, mitosis, and viral/host interaction by controlling the conformation of histone acetylation -dependent chromatin complex es. Studies have shown that I-BET 151 increased ApoA1 expression within the nanomolar range in human hepatic cell line HepG2. The upregulation by I-BET 151 suggested potential anti-inflammatory activi ties upon administration. |
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