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126-07-8 C17H17ClO6 (+)-Griseofulvin

CAS NO.126-07-8

  • Min.Order: 1 Kilogram
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Product Details

Keywords

  • GRISEOFULVIN
  • 6-trimethoxy-6’-methylspiro
  • 6-TRIMETHOXY-6'-METHYL

Quick Details

  • ProName: 126-07-8 C17H17ClO6 (+)-Griseofulvin
  • CasNo: 126-07-8
  • Molecular Formula: C17H17ClO6
  • Appearance: Crystalline Solid
  • Application: 126-07-8 ...
  • DeliveryTime: 7-10 days after payment
  • PackAge: As required
  • Port: Shanghai/Tianjin/Qingdao
  • ProductionCapacity: 100-200 Kilogram/Month
  • Purity: 99%
  • Storage: ?20°C
  • Transportation: By air/sea/express
  • LimitNum: 1 Kilogram
  • Grade: Pharma Grade

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About Certificate

 

1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)

 

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HenNan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
     Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs ,  Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East ,  Africa , South America and some other countries and areas.
    We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you  better with our high - quality products and professional team.
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     We  welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!

Details

Product Name: (+)-Griseofulvin
Synonyms: (+)-GRISEOFULVIN;GRISEOFULVIN;[2S-TRANS]-7-CHLORO-2,4,6-TRIMETHOXY-6'-METHYLSPIRO[BENZOFURAN-2(3H), 1'(2)-CYCLOHEXANE]-3,4'-DIONE;(2S)-TRANS-7-CHLORO-2',4,6-TRIMETHOXY-6'-METHYLSPIRO(BENZOFURAN-2[3H],1'-[2]CYCLOHEXENE)-3,4'-DIONE;7-CHLORO-2',4,6-TRIMETHOXY-6'-METHYL-, (1'S-TRANS)-SPIRO(BENZOFURAN-2(3H),1'-(2)CYCLOHEXENE)-3,4'-DIONE;(+)-griseofulvi;(2s-trans)-7-chloro-2’,4,6-trimethoxy-6’-methylspiro[benzofuran-2(3h),1’-[2]cy;(2s-trans)-xy-6’-methyl
CAS: 126-07-8
MF: C17H17ClO6
MW: 352.77
EINECS: 204-767-4
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Antifungal;Aromatics;Chiral Reagents;VERELAN;Inhibitors
Mol File: 126-07-8.mol
(+)-Griseofulvin Structure
 
(+)-Griseofulvin Chemical Properties
mp  218-220 °C(lit.)
alpha  354 º (c=1, dimethylform)
storage temp.  −20°C
Water Solubility  practically insoluble
Merck  14,4549
BRN  95226
CAS DataBase Reference 126-07-8(CAS DataBase Reference)
NIST Chemistry Reference Griseofulvin(126-07-8)
EPA Substance Registry System Spiro[benzofuran- 2(3H),1'-[2]cyclohexene]- 3,4'-dione, 7-chloro-2',4,6-trimethoxy- 6'-methyl-, (1'S,6'R)-(126-07-8)
 
Safety Information
Hazard Codes  T,Xn
Risk Statements  60-61-40-43-45
Safety Statements  53-22-36/37/39-45
WGK Germany  3
RTECS  WG9800000
Hazardous Substances Data 126-07-8(Hazardous Substances Data)
Chemical Properties It is white or white-like powder. Melting point is 218-224 °C. It is highly soluble in tetrachloroethane, soluble in acetone or chloroform, slightly soluble in methanol or ethanol, and very slightly soluble in water. It is odorless or almost odorless with slightly bitter taste. It is stable to heat.
Production methods Griseofulvin is a antibiotic produced from the culture fermentation broth of Penicillium griseofulvum.
Chemical Properties Crystalline Solid
Category Pesticide
Usage adrenegic blocker, Ca channel blocker, coronary vasodilator, antiarrhythmic
Usage antifungal, inhibits mitosis in metaphase
Usage Griseofulvin is a spirobenzofuran produced by a number of Penicillium species, first isolated in the 1930s by Raistrick's group. Griseofulvin is a selective antifungal agent used to treat skin infections in animals and humans. Griseofulvin acts by binding to fungal tubulin and inhibiting the mitotic spindle. Griseofulvin's ability to bind to keratin is considered an important aspect of the metabolite's access to dermatophytic fungi. More recently, griseofulvin has become an important phenotypic marker in Penicillium taxonomy.
Usage It is an antifungal drug. It is used both in animal and in humans, to treat rigworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum
Toxicity grading Low toxicity
Acute toxicity Oral - rat LD50: 10000 mg / kg; Oral - Mouse LD50: 50000 mg / kg
Flammability hazard characteristics Combustion can produce toxic chloride gas
Storage Characteristics Treasury: ventilation low-temperature an dry; it should be separately stored and transported from raw materials of food.
Extinguishing agent Dry powder, foam, sand
General Description White to pale cream-colored crystalline powder. Odorless or almost odorless. Tasteless. Sublimes without decomposition at 410°F.
Air & Water Reactions Insoluble in water.
Reactivity Profile (+)-Griseofulvin is incompatible with strong oxidizing agents. .
Fire Hazard Flash point data for (+)-Griseofulvin are not available. (+)-Griseofulvin is probably combustible.
 
(+)-Griseofulvin Preparation Products And Raw materials
Raw materials Starch-->Oxalic acid

 

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