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CAS NO.117048-59-6
1(10-100)Metric Ton1(10-100)Metric Ton
| COMBRETASTATIN A-4 Basic information |
| Product Name: | COMBRETASTATIN A-4 |
| Synonyms: | (Z)-2-Methoxy-5-(3,4,5-Trimethoxystyryl)Phenol;(Z)-2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]phenol,3,4,5-Trimethoxy-3hydroxy-4methoxy-(Z)-stilbene,CS-A4;Combrestatin A4( 2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol );(Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol ,98%;2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol;3-[(Z)-2-(3,4,5-Trimethoxyphenyl)ethenyl]-6-methoxyphenol;5-[(Z)-2-(3,4,5-Trimethoxyphenyl)ethenyl]-2-methoxyphenol;Combretastatin A4 |
| CAS: | 117048-59-6 |
| MF: | C18H20O5 |
| MW: | 316.3484 |
| EINECS: | |
| Product Categories: | Inhibitors;Combretastatin;Anti-cancer & immunity;API |
| Mol File: | 117048-59-6.mol |
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| COMBRETASTATIN A-4 Chemical Properties |
| mp | 84.5-85.5°C |
| storage temp. | Desiccate at -20°C |
| Safety Information |
| Hazard Codes | T |
| Risk Statements | 23/24/25-41 |
| Safety Statements | 26-36/37-39-45 |
| RIDADR | UN 2811 |
| COMBRETASTATIN A-4 Usage And Synthesis |
| Chemical Properties | Crystalline Powder |
| Usage | Combretastatin is a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. A potent cytotoxic agent which strongly inhibits the polymerization of tubulin by binding to the colchicine site. |
| Biological Activity | Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo . Acts by inhibiting tubulin polymerization (IC 50 = 2-3 μ M). |
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