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CAS NO.111974-72-2
1(10-100)Kilogram1(100-500)Kilogram2(500-1000)Kilogram
1. Certificate Of Analysis (COA)
2. Material Safety Data Sheet (MSDS)
3. Route of synthesis (ROS)
4. Method of Aanlysis (MOA)
5. Nuclear Magnetic Resonance (NMR)
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| Quetiapine fumarate Basic information |
| Product Name: | Quetiapine fumarate |
| Synonyms: | SEROQUEL;QUETIAPINE FUMARATE;QUETIAPINE HEMIFUMARATE;2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate;DIBENZOTHIAZEPINOHONEP;ICI-204636;QUETIAPINE FUMARATE, 99+%;Quetiapine Fumarate main intermediates |
| CAS: | 111974-72-2 |
| MF: | C46H54N6O8S2 |
| MW: | 883.09 |
| EINECS: | |
| Product Categories: | Active Pharmaceutical Ingredients;Antipsychotic;Intermediates & Fine Chemicals;Pharmaceuticals;Quetiapine;API;Pharmaceutical raw materials;bulk drug material;Inhibitors |
| Mol File: | 111974-72-2.mol |
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| Quetiapine fumarate Chemical Properties |
| mp | 174-176°C |
| storage temp. | -20°C Freezer |
| CAS DataBase Reference | 111974-72-2(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn,N,T,F |
| Risk Statements | 22-50/53-52/53-39/23/24/25-23/24/25-11 |
| Safety Statements | 60-61-45-36/37-16 |
| Quetiapine fumarate Usage And Synthesis |
| Antipsychotics |
Quetiapine fumarate is an antipsychotic, successfully developed by the AstraZeneca United States, it interacts with a variety of neurotransmitter receptors, in the brain, it displays high degree affinity for serotonin (5-HT2) receptor, and it is greater than dopamine D1 and D2 dopamine receptor affinity in the brain. Quetiapine also has high affinity for histamine H1 receptor and adrenergic α1 receptors, and low affinity for α2 receptors, but it basically displays no affinity for cholinergic muscarinic receptors or benzodiazepine receptors . It shows positive results in antipsychotic activity assays such as conditioned avoidance reflex . In clinical, it is mainly used in treatment for adults with severe depression, acute manic episodes of bipolar disorder and schizophrenia of different types . It is not only effective for the positive symptoms of schizophrenia, but also having a certain effect for negative symptoms . It can also alleviate affective symptoms associated with schizophrenia, such as depression, anxiety symptoms and cognitive deficits. The above information is edited by the chemicalbook of Tian Ye. |
| Chemical properties | White crystalline powder. |
| Application | A non-classical antipsychotics. |
| Chemical Properties | White Crystalline Solid |
| Usage | Used as an antipsychotic. Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties |
| Usage | antihypertensive adrenergic receptor blocking agent with selective alpha1- and nonselective beta-adrenergic receptor blocking actions in a single substance. |
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