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CAS NO.111470-99-6
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| Amlodipine besilate Basic information |
| Product Name: | Amlodipine besilate |
| Synonyms: | 2-[(2-AMINOETHOXY)-METHYL]-4-(2-CHLOROPHENYL)-1,4-DIHYDRO-6-METHYL-3,5-PYRIDINEDICARBOXYLIC ACID 3-ETHYL 5-METHYL ESTER BENZENE SULFONATE;2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine benzenesulfonate;AMLODIPINE BENZENESULFONATE;AMLODIPINE BESILATE;AMLODIPINE BESYLATE;NORVASC;3,5-pyridinedicarboxylicacid,2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,;4-dihydro-6-methyl-,3-ethyl-5-methylester,monobenzenesulfonate |
| CAS: | 111470-99-6 |
| MF: | C26H31ClN2O8S |
| MW: | 567.05 |
| EINECS: | |
| Product Categories: | Active Pharmaceutical Ingredients;Dihydropyridine Class Chemicals;Intermediates & Fine Chemicals;Pharmaceuticals;Amlodipine;Aromatics;Dihydropyridine;Heterocycles;BENICAR;AZD929;Fine Chemical |
| Mol File: | 111470-99-6.mol |
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| Amlodipine besilate Chemical Properties |
| mp | 199-201°C |
| storage temp. | Store at RT |
| solubility | DMSO: 20 mg/mL |
| form | solid |
| color | white |
| CAS DataBase Reference | 111470-99-6(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38-20/21/22 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | US7967700 |
| Hazardous Substances Data | 111470-99-6(Hazardous Substances Data) |
| Amlodipine besilate Usage And Synthesis |
| Chemical Properties | White Crystalline Solid |
| Usage | A dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive |
| Usage | Angiotensin II inhibitor prodrug, antihypertensive |
| Usage | Amlodipine besylate is a L-type calcium channel blocker which may be used for the treatment of angina pectoris and hypertension. Amlodipine also inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats. |
| Biological Activity | L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca 2+ -induced contractions in depolarized rat aorta (IC 50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC 50 = 25 μ M). |