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HENAN SUNLAKE ENTERPRISE CORPORATION

Country: China (Mainland)

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Tacrolimus

CAS NO.104987-11-3

  • Min.Order: 1 Kilogram
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Product Details

Keywords

  • Tacrolimus
  • 104987-11-3
  • manufacturer , better price with good quality

Quick Details

  • ProName: Tacrolimus
  • CasNo: 104987-11-3
  • Molecular Formula: C44H69NO12
  • Appearance: White Crystalline Solid
  • Application: Pharmaceuticals
  • DeliveryTime: Within 7 days
  • PackAge: Depended
  • Port: China Main Ports
  • ProductionCapacity: 300 Kilogram/Month
  • Purity: 98%
  • Storage: KEEP COLD
  • Transportation: BY SEA OR AIR
  • LimitNum: 1 Kilogram

Superiority


Preview
CBNumber: CB9772399
Chemical Name: Tacrolimus
Molecular Formula: C44H69NO12
Formula Weight: 804.02
CAS No.: 104987-11-3
Tacrolimus Basic information
Product Name: Tacrolimus
Synonyms: (2-propenyl)-,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*,8s*,9e,12r*,14r*,15s*,16r*,18s*;,19s*,26ar*))-;16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1;19-epoxy-3h-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4h,23h)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-14,16-dim;6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-5;fr900506;prograf;tsukubaenolide
CAS: 104987-11-3
MF: C44H69NO12
MW: 804.02
EINECS:  
Product Categories: Active Pharmaceutical Ingredients;Immunosuppressant.;Intermediates & Fine Chemicals;Pharmaceuticals;API;Chiral Reagents;Fujimycin, Prograf;antibiotic;Inhibitors
Mol File: 104987-11-3.mol
Tacrolimus Structure
 
Tacrolimus Chemical Properties
mp  113-115°C
storage temp.  −20°C
solubility  DMSO: >3 mg/mL
form  solid
color  white
CAS DataBase Reference 104987-11-3(CAS DataBase Reference)
 
Safety Information
Hazard Codes  T,Xi,Xn,F
Risk Statements  25-36/37/38-36-20/21/22-11
Safety Statements  45-36-26-36/37-16
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  KD4201200
MSDS Information
 
 
Tacrolimus Usage And Synthesis
Chemical Properties White Crystalline Solid
Usage An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.
Usage FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system
Usage Tacrolimus (fujimycin) was discovered as a potent inhibitor of IL2 production in a targeted search for novel immunosuppressants. Tacrolimus acts by blocking T cell proliferation in vitro by inhibiting the generation of several lymphokines, notably the original target IL-2. Tacrolimus inhibits the activity of FK-506 binding protein, Ca2+-dependent phosphatase and calcineurin, and activates NF-κB through phosphorylation and degradation of IκBα.
Usage treatment of Cushing's syndrome
Usage For use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart,
 
Tacrolimus Preparation Products And Raw materials
Raw materials Ethyl acetate-->Celite -->Starch-->Yeast extract-->Active Calcium

 

Details

Henan Sunlake Enterprise Corporation is located in Henan Province, the central plain of China , Which enjoys favorable geogeaphical position and convenient transportion. The comany was established in june 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
     Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs ,  Water treatment chemicals , Food & FEED additives and others . These products have been being well exported to Europe , Southeast Asia , the Middle East ,  Africa , South America and some other countries and areas.
    We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team who are professional engineers and scholars with Ph. D. .So we are confident to serve you  better with our high - quality products and professional team.
    We are taking great efforts to provide our customers with demanded goods and professional services, continuously improve our core ability of competition and get the momentum for sustainable development ,Which finally makes us being a reliable and professional supplier in international market.
     We welcome any inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!
 
Our Advantages:
I). We have abundant professional production experience.
II). We have our own chemical factory.
III). Sample is free of charge.
IV). Reasonable Price, Excellent Quality & Attentive Service
V). Prompt reply: we can reply your inquiry and email within 24 hours.
VI). Fast Delivery: The delivery time is about 10-20 days after receiving the deposit.
VII). We have passed the LFGB, SGS, STC, HSL and some other tests.
VIII). We have a unity cooperation team.
 
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