HENAN SUNLAKE ENTERPRISE CORPORATION
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Tel: +86-371- 86259723
Tel: 17734809689
Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
Mobile: 17734809689
Tel: +86-371- 86259723
Fax: +86-371- 86259723
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City: ZHENGZHOU
Street: Mingmen International Center, NO.222 Dongming Road,Zhengzhou,Henan,China
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CAS NO.88-32-4
1(10-100)Gram1(100-200)Gram
| FASUDIL Basic information |
| Product Name: | FASUDIL |
| Synonyms: | FASUDIL;1-(5-ISOQUINOLINE-SULFONYL)-HOMOPIPERAZINE;at877;hexahydro-1-(5-isoquinolinylsulfonyl)-1h-4-diazepine;HA-1077 DIHYDROCHLORIDE NOVEL VASODILATO R AGE;HA 1077, DIHYDROCHLORIDE, 99+%;Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine;HA-1077：Eril |
| CAS: | 103745-39-7 |
| MF: | C14H17N3O2S |
| MW: | 291.37 |
| EINECS: | |
| Product Categories: | Protein Kinase Inhibitors and Activators;Protein Kinase;Signalling;Angiogenesis and Metastasis;Intracellular signaling;APIs;ERIL |
| Mol File: | 103745-39-7.mol |
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| FASUDIL Chemical Properties |
| storage temp. | Store at RT |
| solubility | H2O: >200 mg/mL |
| form | solid |
| color | white |
| CAS DataBase Reference | 103745-39-7(CAS DataBase Reference) |
| Safety Information |
| WGK Germany | 3 |
| RTECS | HM4031166 |
| FASUDIL Usage And Synthesis |
| Chemical Properties | White Crystalline Solid |
| Usage | vasodilator (cerebral), Ca antagonist |
| Usage | A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced co ntraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho- associated Kinase (ROCK IC50= 10.7 uM). |
| Biological Activity | Cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM). Ca2+ antagonist and vasodilator. Also inhibits proliferation of vascular smooth muscle cells. |
| FASUDIL Preparation Products And Raw materials |
| Raw materials | Isoquinoline |
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