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CAS NO.761446-44-0
1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Basic information |
Product Name: | 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole |
Synonyms: | 1-METHYL-4-1H-PYRAZOLEBORONIC ACID, PINACOL ESTER;1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-1H-PYRAZOLE;1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE;1-METHYL-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER;1-METHYLPYRAZOLE-4-BORONIC ACID PINACOL ESTER;1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 97+%;1-Methyl-4-(4,4,5,5-Tetramethy;1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2- |
CAS: | 761446-44-0 |
MF: | C10H17BN2O2 |
MW: | 208.07 |
EINECS: | |
Product Categories: | Organoborons;Pyrazole;Boronic acid;Heterocyclic Building Blocks;Boronate Esters;Boronic Acids and Derivatives;Chemical Synthesis;Heteroaryl Boronate Esters;Organometallic Reagents |
Mol File: | 761446-44-0.mol |
1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Chemical Properties |
mp | 59-64 °C(lit.) |
storage temp. | Refrigerator (+4°C) |
CAS DataBase Reference | 761446-44-0(CAS DataBase Reference) |
Safety Information |
Hazard Codes | Xn,F,Xi |
Risk Statements | 22-36/37/38 |
Safety Statements | 26-36-37/39 |
WGK Germany | 3 |
Hazard Note | Irritant/Flammable |
HazardClass | IRRITANT |
1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Usage And Synthesis |
Chemical Properties | White to light yellow crystal powde |
Usage | Reagent used for• ;Suzuki-Miyaura cross-coupling reactions1,2,3• ;Transesterification reactions4Reagent used for preparation of• ;Aminothiazoles as γ-secretase modulators5• ;Amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy6• ;Pyridine derivatives as TGF-β1 and activin A signalling inhibitors7• ;MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer8 |
Usage | suzuki reaction |
1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Preparation Products And Raw materials |
Raw materials | Tetrahydrofuran-->Potassium hydroxide -->n-Butyllithium-->Iodomethane-->Trimethyl borate-->Methyl bromide -->Pinacol-->MOLECULAR SIEVE-->4-Bromopyrazole |
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