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CAS NO.75695-93-1
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Isradipine Basic information |
Product Name: | Isradipine |
Synonyms: | 4-(4-BENZOFURAZANYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID METHYL 1-METHYLETHYL ESTER;4-(2,1,3-BENZOXADIAZOL-4-YL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINECARBOXYLIC ACID METHYL 1-METHYLETHYL ESTER;Isradipin;4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Methyl 1-Methylethyl Ester;Clivoten;DynaCirc;Esradin;Isrodipine |
CAS: | 75695-93-1 |
MF: | C19H21N3O5 |
MW: | 371.39 |
EINECS: | |
Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Calcium channel;Ion Channels;ALLEGRA |
Mol File: | 75695-93-1.mol |
Isradipine Chemical Properties |
mp | 166-1680C |
storage temp. | 2-8°C |
solubility | DMSO: ~26 mg/mL |
form | solid |
color | yellow |
CAS DataBase Reference | 75695-93-1(CAS DataBase Reference) |
NIST Chemistry Reference | Isradipine(75695-93-1) |
Safety Information |
Safety Statements | 22-24/25 |
WGK Germany | 3 |
MSDS Information |
Provider | Language |
---|---|
4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester | English |
SigmaAldrich | English |
Isradipine Usage And Synthesis |
Chemical Properties | Yellow Solid |
Usage | Dihydropyridine calcium channel blocker. Antihypertensive; antianginal |
Usage | nonsedating H1-antihistamine |
Biological Activity | Potent and selective L-type voltage-gated Ca 2+ channel blocker. EC 50 and pA 2 values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca 2+ -induced contractions of rabbit aorta respectively; EC 25 = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo , exerting primary effects on vascular tissue with secondary negative chronotropic action. |
Isradipine Preparation Products And Raw materials |
Raw materials | Methyl 3-aminocrotonate-->Isopropyl acetoacetate-->Benzofuroxan |