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Tel: 17734809689
Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
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Tel: +86-371- 86259723
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CAS NO.738-70-5
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
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About Company
| Product Name: | Trimethoprim |
| Synonyms: | abaprim;5-((3,4,5-trimethoxyphenyl)methyl)-2,4-pyrimidinediamine;5-(3,4,5-trimethoxybenzyl)-2,4-diaminopyrimidine;5-(3,4,5-TRIMETHOXYBENZYL)PYRIMIDINE-2,4-DIYLAMINE;2,4-DIAMINO-5-(3,4,5-TRIMETHOXYBENZYL)PYRIMIDE;2,4-DIAMINO-5-(3',4',5'-TRIMETHOXYBENZYL)PYRIMIDINE;2,4-DIAMINO-5-(3,4,5-TRIMETHOXYBENZYL)PYRIMIDINE;TRIMETOPRIM |
| CAS: | 738-70-5 |
| MF: | C14H18N4O3 |
| MW: | 290.32 |
| EINECS: | 212-006-2 |
| Product Categories: | Pharmaceutical;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Peptide Synthesis/Antibiotics;TRIMPEX;antibiotic;Broad-spectrum antibacterials;API |
| Mol File: | 738-70-5.mol |
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| Trimethoprim Chemical Properties |
| mp | 199-203 °C |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble |
| form | white powder |
| Water Solubility | <0.1 g/100 mL at 24 ºC |
| Merck | 9709 |
| Stability: | Stable. Incompatible with strong oxidizing agents, acids. |
| CAS DataBase Reference | 738-70-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Trimethoprim(738-70-5) |
| EPA Substance Registry System | 2,4-Pyrimidinediamine, 5-[(3,4,5-trimethoxyphenyl) methyl]-(738-70-5) |
| Safety Information |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | UV8225000 |
| F | 8-10-21 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29335995 |
| Hazardous Substances Data | 738-70-5(Hazardous Substances Data) |
| Chemical Properties | White crystalline powder, odorless, bitter taste. Melting point: 199-203 °C. It is insoluble in water, ether, benzene, and slightly soluble in chloroform, methanol, highly soluble in acetic acid. |
| Application |
1. It can be used as a synergistic antimicrobial drugs; it can also be used for treating bacterial infections and coccidiosis in poultry. 2. It is a novel orally administrated broad-spectrum antibiotics. It has a similar antibacterial spectrum with sulfa drugs but with a stronger potency. It is effective in treating a variety of Gram positive and negative bacteria. Since the bacteria is easy to evolve drug resistance to this product, it is not suitable to be used alone as an antimicrobial drug. The combination between trimethoprim and sulfa drugs can enhance the antibacterial activity by several times to several dozens of times. The product is mainly used for being as the synergistic drugs for sulfonamide drugs with a general ratio of 1: 5 for usage. It can also be used as a veterinary drug for treatment of avian sepsis caused by Escherichia coli, salmonellosis, fowl typhoid, cholera, and respiratory system secondary bacterial infections. It can also be used for the treatment of coccidiosis. 3. Application: used as antibacterial synergistic drugs; treat respiratory tract infections, urinary tract infections and intestinal infections when being used alone. The above information is edited by the chemicalbook of Dai xiongfeng. |
| Production methods | Use Trimethoxybenzaldehyde as raw material; first condense with methoxypropionitrile to produce 3'4'5'- trimethoxy-2-cyano-3-methoxy-propene; and cyclized together with guanidine nitrate in the presence of methanol / sodium methoxide. |
| Chemical Properties | Crystalline |
| Usage | Antibacterial. |
| Usage | anti-inflammatory |
| General Description | Odorless white powder. Bitter taste. |
| Air & Water Reactions | Insoluble in water. |
| Reactivity Profile | Trimethoprim readily forms salts with acids. . |
| Fire Hazard | Flash point data for Trimethoprim are not available. Trimethoprim is probably combustible. |
| Trimethoprim Preparation Products And Raw materials |
| Raw materials | Etanol-->Ethyl acetate-->Acetic acid glacial-->Sodium methanolate-->Acrylonitrile-->Guanidine nitrate-->Red prussiate-->2,3,4-Trimethoxybenzaldehyd |