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CAS NO.69-52-3
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Preview |
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| Ampicillin sodium Basic information |
| Product Name: | Ampicillin sodium |
| Synonyms: | 6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-,sodiumsalt,d-(-)-4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid;Alpen-n;Amcill-s;Binotalsodium;Citteral;D-6-(-Amino-phenylacetamido)penicillanicacidsodiumsalt;Domicillin;omnipen-n |
| CAS: | 69-52-3 |
| MF: | C16H18N3NaO4S |
| MW: | 371.39 |
| EINECS: | 200-708-1 |
| Product Categories: | Antibiotic Explorer;veterinary medicine,soluble powder;Pharma;API;OMNIPEN;antibiotic;semisynthetic broad-spectrum penicillin;Pharmaceutical raw chemicals;Inhibitors |
| Mol File: | 69-52-3.mol |
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| Ampicillin sodium Chemical Properties |
| mp | 215 °C (dec.)(lit.) |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL, clear, very faintly yellow |
| form | powder |
| color | white with slight yellow cast |
| CAS DataBase Reference | 69-52-3(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi,Xn |
| Risk Statements | 42/43-36/37/38-22 |
| Safety Statements | 22-36/37-45-36-26 |
| WGK Germany | 2 |
| RTECS | XH8400000 |
| F | 3-10 |
| HS Code | 29419000 |
| MSDS Information |
| Provider | Language |
|---|---|
| Ampicillin sodium | English |
| SigmaAldrich | English |
| Ampicillin sodium Usage And Synthesis |
| Broad-spectrum penicillin |
Ampicillin sodium is a broad-spectrum penicillin, its antibacterial spectrum is broader than penicillin , it has antibacterial activity on some gram-negative bacteria (such as Haemophilus influenzae, Escherichia coli, Proteus mirabilis) . Its effects on gram-positive cocci are similar to penicillin. Enzymatic hydrolysis of penicillin produced by bacteria may also make it inactive. It is clinically applicable in the treatment of respiratory infections, urinary tract infections, gastrointestinal tract infections, skin and soft tissue infections, meningitis, septicemia, endocarditis caused by sensitive bacteria. This product is a drug of choice for enterococcal infections. The above information is edited by the chemicalbook of Tian Ye. |
| Chemical Properties | White or almost white powder or crystal. Soluble in water, slightly soluble in ethanol, insoluble in ether. Hygroscopic, when it is set at room temperature in an aqueous solution ,it gradually turns yellow,produces turbidity, decreases potency. Odorless, slightly bitter taste. |
| Application | A semi-synthetic broad-spectrum penicillin,it is mainly used for treatment of penicillin-sensitive gram-positive bacteria, Escherichia coli, Proteus, Salmonella, Shigella and other. |
| production method | It is derived from the ampicillin salifying : Ampicillin is suspended in water, adjust to pH 9 with sodium hydroxide solution, dissolve and filter . The filtrate is added active carbon, and is filtered and the filtrate is dried at a low temperature, to obtain the product. |
| Category | Toxic substances |
| Toxicity grading | Low toxic |
| Acute toxicity | Oral - rat LD50:> 5314 mg / kg; Oral - Mouse LD50:> 5314 mg / kg. |
| Flammability and hazard characteristics | Combustion produces toxic sodium oxide, nitrogen oxide and sulfur oxide gases. |
| Storage Characteristics | Ventilated, low-temperature ,dry storeroom. |
| Extinguishing agent | Water, dry powder, foam, sand. |
| Chemical Properties | White powder |
| Usage | antibacterial |
| Usage | diuretic, anti-hypertensive |
| Ampicillin sodium Preparation Products And Raw materials |
| Raw materials | Sodium hydroxide-->Ethyl acetate-->Isopropanol-->2-Ethylhexanoic acid |