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6284-40-8 C7H17NO5 Meglumine

CAS NO.6284-40-8

  • Min.Order: 10 Gram
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Product Details

Keywords

  • 6284-40-8 C7H17NO5 Meglumine
  • 6284-40-8
  • C7H17NO5

Quick Details

  • ProName: 6284-40-8 C7H17NO5 Meglumine
  • CasNo: 6284-40-8
  • Molecular Formula: C7H17NO5
  • Appearance: white powder
  • DeliveryTime: 5-7 days after payment
  • PackAge: Woven bag
  • Port: Tianjin Shanghai
  • ProductionCapacity: 1 Kilogram/Day
  • Purity: 99%
  • Storage: Normal temperature
  • LimitNum: 10 Gram

Superiority

Meglumine Basic information
Product Name: Meglumine
Synonyms: N-Methyl-D-Glu;METHYL GLUCAMINE MEGLUMINE;MEGLUMINE, USP;N-Methylglucamine (Meglumine);N-Methyl-D-Glucamine>99%;MeglumineAntimoniateBase;N-METHYL-D-GLUCANINE;MEGLUMINE(N-METHYLGLUCAMINE)
CAS: 6284-40-8
MF: C7H17NO5
MW: 195.21
EINECS: 228-506-9
Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Aminosugars;Diagnostic agents;Biochemistry;Sugars;PREDEF;-;API
Mol File: 6284-40-8.mol
Meglumine Structure
 
Meglumine Chemical Properties
Melting point  129-131.5 °C(lit.)
alpha  -16.5 º (c=10, H2O, on dry sub)
Boiling point  331.88°C (rough estimate)
density  1.2669 (rough estimate)
refractive index  -16.5 ° (C=2, H2O)
RTECS  LZ4295770
storage temp.  Store below +30°C.
solubility  H2O: 0.1 g/mL, clear, colorless
form  Crystalline Powder
pka pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)
color  White to almost white
PH 11 (10g/l, H2O, 20℃)
optical activity [α]20/D 16.5±0.5°, c = 2% in H2O
Water Solubility  100 g/100 mL (25 ºC)
Sensitive  Air Sensitive & Hygroscopic
Merck  14,6078
BRN  385906
InChIKey MBBZMMPHUWSWHV-VZFHVOOUSA-N
NIST Chemistry Reference N-methylglucamine(6284-40-8)
EPA Substance Registry System D-Glucitol, 1-deoxy-1-(methylamino)-(6284-40-8)
 
Safety Information
Risk Statements  36/37/38
Safety Statements  24/25
WGK Germany  3
3-10-23
Autoignition Temperature ~662 °F
TSCA  Yes
HS Code  29221980
Toxicity LD50 orally in Rabbit: > 5000 mg/kg
MSDS Information
Provider Language
Meglumine English
SigmaAldrich English
ACROS English
ALFA English
 
Meglumine Usage And Synthesis
Chemical Properties white to almost white crystalline powder
Chemical Properties Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.
Uses antiinflammatory
Uses excipient in cosmetics and X-ray contrast media
Definition ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.
Production Methods Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation.
Brand name Renovue (Bracco).
Pharmaceutical Applications Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media.
Safety Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient. 
LD50 (mouse, IP): 1.68 g/kg
storage Meglumine does not polymerize or dehydrate unless heated above 150°C for prolonged periods.
The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended.
Purification Methods Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.]
Incompatibilities Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide.
Regulatory Status Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK.
 
Meglumine Preparation Products And Raw materials
Raw materials ACETALDEHYDE AMMONIA-->1-Glucose-methylamine schiffbase

 

Details

Meglumine Basic information
Product Name: Meglumine
Synonyms: N-Methyl-D-Glu;METHYL GLUCAMINE MEGLUMINE;MEGLUMINE, USP;N-Methylglucamine (Meglumine);N-Methyl-D-Glucamine>99%;MeglumineAntimoniateBase;N-METHYL-D-GLUCANINE;MEGLUMINE(N-METHYLGLUCAMINE)
CAS: 6284-40-8
MF: C7H17NO5
MW: 195.21
EINECS: 228-506-9
Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Aminosugars;Diagnostic agents;Biochemistry;Sugars;PREDEF;-;API
Mol File: 6284-40-8.mol
Meglumine Structure
 
Meglumine Chemical Properties
Melting point  129-131.5 °C(lit.)
alpha  -16.5 º (c=10, H2O, on dry sub)
Boiling point  331.88°C (rough estimate)
density  1.2669 (rough estimate)
refractive index  -16.5 ° (C=2, H2O)
RTECS  LZ4295770
storage temp.  Store below +30°C.
solubility  H2O: 0.1 g/mL, clear, colorless
form  Crystalline Powder
pka pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)
color  White to almost white
PH 11 (10g/l, H2O, 20℃)
optical activity [α]20/D 16.5±0.5°, c = 2% in H2O
Water Solubility  100 g/100 mL (25 ºC)
Sensitive  Air Sensitive & Hygroscopic
Merck  14,6078
BRN  385906
InChIKey MBBZMMPHUWSWHV-VZFHVOOUSA-N
NIST Chemistry Reference N-methylglucamine(6284-40-8)
EPA Substance Registry System D-Glucitol, 1-deoxy-1-(methylamino)-(6284-40-8)
 
Safety Information
Risk Statements  36/37/38
Safety Statements  24/25
WGK Germany  3
3-10-23
Autoignition Temperature ~662 °F
TSCA  Yes
HS Code  29221980
Toxicity LD50 orally in Rabbit: > 5000 mg/kg
MSDS Information
Provider Language
Meglumine English
SigmaAldrich English
ACROS English
ALFA English
 
Meglumine Usage And Synthesis
Chemical Properties white to almost white crystalline powder
Chemical Properties Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.
Uses antiinflammatory
Uses excipient in cosmetics and X-ray contrast media
Definition ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.
Production Methods Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation.
Brand name Renovue (Bracco).
Pharmaceutical Applications Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media.
Safety Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient. 
LD50 (mouse, IP): 1.68 g/kg
storage Meglumine does not polymerize or dehydrate unless heated above 150°C for prolonged periods.
The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended.
Purification Methods Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.]
Incompatibilities Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide.
Regulatory Status Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK.
 
Meglumine Preparation Products And Raw materials
Raw materials ACETALDEHYDE AMMONIA-->1-Glucose-methylamine schiffbase
   HenNan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material . 
   Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas. 
    We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team. 
     We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market. 
We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!
 
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