Details
Meglumine Basic information |
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Meglumine Chemical Properties |
Melting point |
129-131.5 °C(lit.) |
alpha |
-16.5 º (c=10, H2O, on dry sub) |
Boiling point |
331.88°C (rough estimate) |
density |
1.2669 (rough estimate) |
refractive index |
-16.5 ° (C=2, H2O) |
RTECS |
LZ4295770 |
storage temp. |
Store below +30°C. |
solubility |
H2O: 0.1 g/mL, clear, colorless |
form |
Crystalline Powder |
pka |
pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate) |
color |
White to almost white |
PH |
11 (10g/l, H2O, 20℃) |
optical activity |
[α]20/D 16.5±0.5°, c = 2% in H2O |
Water Solubility |
100 g/100 mL (25 ºC) |
Sensitive |
Air Sensitive & Hygroscopic |
Merck |
14,6078 |
BRN |
385906 |
InChIKey |
MBBZMMPHUWSWHV-VZFHVOOUSA-N |
NIST Chemistry Reference |
N-methylglucamine(6284-40-8) |
EPA Substance Registry System |
D-Glucitol, 1-deoxy-1-(methylamino)-(6284-40-8) |
Risk Statements |
36/37/38 |
Safety Statements |
24/25 |
WGK Germany |
3 |
F |
3-10-23 |
Autoignition Temperature |
~662 °F |
TSCA |
Yes |
HS Code |
29221980 |
Toxicity |
LD50 orally in Rabbit: > 5000 mg/kg |
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Meglumine Usage And Synthesis |
Chemical Properties |
white to almost white crystalline powder |
Chemical Properties |
Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor. |
Uses |
antiinflammatory |
Uses |
excipient in cosmetics and X-ray contrast media |
Definition |
ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis. |
Production Methods |
Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation. |
Brand name |
Renovue (Bracco). |
Pharmaceutical Applications |
Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media. |
Safety |
Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient.
LD50 (mouse, IP): 1.68 g/kg |
storage |
Meglumine does not polymerize or dehydrate unless heated above 150°C for prolonged periods.
The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended. |
Purification Methods |
Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.] |
Incompatibilities |
Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide. |
Regulatory Status |
Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK. |
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Meglumine Preparation Products And Raw materials |
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