HENAN SUNLAKE ENTERPRISE CORPORATION
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Tel: 17734809689
Tel: 17734809689
Tel: 86-371-86259723
Tel: 17734809689
Tel: 17734809689
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Tel: +86-371- 86259723
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CAS NO.62-46-4
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
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About Company
| Product Name: | Lipoic acid |
| Synonyms: | (R)-LIPOIC ACID;6,8-Thioctic acid;6,8-Thiocticacid;6,8-Thiotic acid;6,8-Thioticacid;6-Thioctic acid;6-Thiocticacid;6-Thiotic acid |
| CAS: | 62-46-4 |
| MF: | C8H14O2S2 |
| MW: | 206.33 |
| EINECS: | 200-534-6 |
| Product Categories: | PHARMACEUTICALS;FINE Chemical & INTERMEDIATES;chiral;API;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Pharmaceutical intermediates;Inhibitors |
| Mol File: | 62-46-4.mol |
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| Lipoic acid Chemical Properties |
| mp | 48-52 °C(lit.) |
| Fp | >230 °F |
| CAS DataBase Reference | 62-46-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Lipoic acid(62-46-4) |
| Safety Information |
| WGK Germany | 3 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| Lipoic acid Usage And Synthesis |
| B vitamins |
Lipoic acid is a class of compounds belonging to the B class vitamins and is the growth factor of yeast and some kinds of microorganisms. It can play the role of coenzyme role in a multi-enzyme system that is responsible for catalyzing the acyl transfer effect in the reaction of oxidative decarboxylation of pyruvate into acetate and oxidative decarboxylation reaction of α- ketoglutarate into succinic acid. Its chemical name is 5- [3-(1,2 - dithiol hetero-cycle)] pentanoic acid. The appearance is pale yellow crystals with the molecular weight being 206.33. DL- body: the melting point is 60 ~ 61 ℃. L- body (natural products): the melting point is 45 ~ 47.5 ℃. Optical rotation [α] D23 + 113 ℃. D- body (natural products): the melting point is 46 ~ 48 ℃. Optical rotation [α] D23 + 104 ℃. It is soluble in organic solvents but insoluble in water. It can be used for the prevention and treatment of acute hepatitis, liver cirrhosis, hepatic coma, fatty liver and other diseases. The natural material is found in the liver, kidneys and heart. Synthetic products is obtained through condensation of ethylene and adipic acid mono-ester chloride in the presence of aluminum chloride into chloropropionyl pivaloyl ester, which further has condensation reaction with sulfuric acid, then go through reduction with sodium borohydride and sodium hydroxide hydrolysis, and finally have reaction with thiourea to obtain it. 6,8-lipoic acids can be dissolved in water and can often be presented together with vitamin B1. There are two forms including oxidized and reduced (6,8- dimercapto octanoic acid) types. Inside the body of organisms, some hydrogen group and acyl group can be accepted or transferred through the conversion of these two forms. It can be taken as the coenzyme of the α- keto acid oxidation decarboxylase and hydroxyethyl enzyme and play the role of acyl and hydrogen group transfer during metabolic pathways. Since the human body can synthesize it, no cases of deficiency have been reported before. However, it is indispensable factors for the growth and development of some microorganisms and protozoa. It is rich in liver and yeast. The above information is edited by the chemicalbook of Dai Xiongfeng. |
| Application |
It is a kind of B vitamins and can be used for the treatment of acute and chronic hepatitis, cirrhosis, hepatic coma, fatty liver, diabetes, etc. It can be used as a kind of antioxidants |
| Chemical Properties | Thioctic acid, 6,8-dithiooctanoic acid |
| Usage | hydrogen-transferring cofactor, potentiating anti-oxidant |
| Lipoic acid Preparation Products And Raw materials |
| Raw materials | Ethyl 6,8-dichlorooctanoate-->Ethyl 6,8-dichloro caprylate |