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CAS NO.587871-26-9
| KU-55933 (ATM Kinase Inhibitor) Basic information |
| Product Name: | KU-55933 (ATM Kinase Inhibitor) |
| Synonyms: | 2-MORPHOLIN-4-YL-6-THIANTHREN-1-YL-PYRAN-4-ONE;2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one;KU-55933 (ATM Kinase Inhibitor);KU-55933, >99%;KV-55933;2-morpholino-6-(thianthren-1-yl)-4H-pyran-4-one;2-Morpholin-4-yl-6-thianthren-1-ylpyran-4-one KU-55933 (ATM Kinase Inhibitor);KU 55933, >=98% |
| CAS: | 587871-26-9 |
| MF: | C21H17NO3S2 |
| MW: | 395.49 |
| EINECS: | |
| Product Categories: | Inhibitors |
| Mol File: | 587871-26-9.mol |
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| KU-55933 (ATM Kinase Inhibitor) Chemical Properties |
| storage temp. | Desiccate at -20°C |
| KU-55933 (ATM Kinase Inhibitor) Usage And Synthesis |
| Usage | A potent and specific ATM kinase inhibitor with an IC50 and a Ki of 13 nM and 2.2 nM, respectively. |
| Biological Activity | Potent, selective and competitive ATM kinase inhibitor (K i = 2.2 nM, IC 50 values are 13, 2500, 9300, 16600, > 100000 and > 100000 nM at ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively). Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21 CIP1 levels in vitro . Acts as a radio- and chemosensitizer for the treatment of cancer. |
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